PMID- 10555287
OWN - NLM
STAT- MEDLINE
DCOM- 19991123
LR  - 20180109
IS  - 0737-4038 (Print)
IS  - 0737-4038 (Linking)
VI  - 16
IP  - 11
DP  - 1999 Nov
TI  - Concerted evolution of exons and introns in the MHC-linked tenascin-X gene of 
      mammals.
PG  - 1558-67
AB  - Two modes of evolution of repeated domains in proteins have been described: (1) a 
      conservative mode, whereby individual domains are conserved across gene 
      duplication and speciation events, and (2) a concerted mode, whereby repeat 
      domains become homogenized within a gene, presumably by intragenic partial 
      duplication and/or gene conversion. The evolution of repeated EGF-like and 
      fibronection-type-III-like (Fn-III) domains in the vertebrate extracellular 
      matrix proteins tenascin-X (TNX) and tenascin-C (TNC) was studied by comparisons 
      between human and mouse orthologs and between the paralogous TNC and TNX genes. 
      The EGF-like repeats have largely been homogenized within each gene by concerted 
      evolution since the duplication of the two genes but have been conserved since 
      the divergence of rodents and primates. The Fn-III domains of TNC have likewise 
      mainly evolved in a conservative fashion since the divergence of rodents and 
      primates. In contrast, the Fn-III repeats of TNX fall into three distinct 
      categories with regard to mode of evolution: (1) The three C-terminal repeats 
      have been conserved since before duplication of the TNX and TNC genes. (2) 
      Certain other repeats have been homogenized within each gene since gene 
      duplication but have been conserved since the divergence of rodents and primates. 
      (3) Still other repeats have evolved in a concerted fashion in rodent and primate 
      lineages since their divergence. Remarkably, certain introns adjacent to the 
      exons encoding these concertedly evolving Fn-III repeats have themselves evolved 
      in a concerted fashion. This is the first known example of concerted evolution of 
      repeated introns within a protein-coding gene.
FAU - Hughes, A L
AU  - Hughes AL
AD  - Department of Biology, Pennsylvania State University, USA. alh13@psu.edu
LA  - eng
GR  - R01-GM34940/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Biol Evol
JT  - Molecular biology and evolution
JID - 8501455
RN  - 0 (Tenascin)
RN  - 0 (tenascin X)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - DNA
MH  - *Evolution, Molecular
MH  - *Exons
MH  - Fibrinogen/genetics
MH  - Humans
MH  - *Introns
MH  - Major Histocompatibility Complex/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Tenascin/chemistry/*genetics
EDAT- 1999/11/11 00:00
MHDA- 1999/11/11 00:01
CRDT- 1999/11/11 00:00
PHST- 1999/11/11 00:00 [pubmed]
PHST- 1999/11/11 00:01 [medline]
PHST- 1999/11/11 00:00 [entrez]
AID - 10.1093/oxfordjournals.molbev.a026068 [doi]
PST - ppublish
SO  - Mol Biol Evol. 1999 Nov;16(11):1558-67. doi: 
      10.1093/oxfordjournals.molbev.a026068.