PMID- 10558965
OWN - NLM
STAT- MEDLINE
DCOM- 20000110
LR  - 20081121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 180
IP  - 6
DP  - 1999 Dec
TI  - Reactivation of human herpesvirus 6 during pregnancy.
PG  - 2035-8
AB  - Reactivation of human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) during 
      pregnancy and transmission of the viruses to the fetus were investigated by 
      polymerase chain reaction (PCR) and serology. In all, 104 blood samples were 
      obtained 3 times during pregnancy and once at delivery. In another 107 women, 
      samples were obtained only at delivery. Cord blood samples were obtained from 
      both groups of women. HHV-6 DNA was detected in 41%-44% of the samples during 
      months 3-8 of pregnancy, in 25% at delivery, and in 24% of age-matched controls. 
      HHV-6 DNA was found in 1.0% of the cord blood samples. CMV DNA was detected in 
      1.7% of leukocytes from 104 pregnant women but in no cord blood sample. IgG 
      antibodies to HHV-6 were found in 96% and CMV IgG in 62.5% of the women. HHV-6 
      IgG titers were significantly higher in HHV-6 PCR-positive women. Thus, HHV-6 
      reactivation seems common during pregnancy, and transfer of HHV-6 to the fetus 
      may occur in approximately 1% of pregnancies.
FAU - Dahl, H
AU  - Dahl H
AD  - Swedish Institute for Infectious Disease Control and Microbiology and 
      Tumorbiology Centre, Karolinska Institute, Uppsala, Sweden. Helena.Dahl@smi.ki.se
FAU - Fjaertoft, G
AU  - Fjaertoft G
FAU - Norsted, T
AU  - Norsted T
FAU - Wang, F Z
AU  - Wang FZ
FAU - Mousavi-Jazi, M
AU  - Mousavi-Jazi M
FAU - Linde, A
AU  - Linde A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - Cytomegalovirus/genetics/growth & development/immunology
MH  - Cytomegalovirus Infections/transmission/virology
MH  - DNA, Viral/analysis
MH  - Female
MH  - Fetal Blood/virology
MH  - Herpesviridae Infections/*transmission/*virology
MH  - Herpesvirus 6, Human/genetics/*growth & development/immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Infant, Newborn
MH  - Infectious Disease Transmission, Vertical
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/*virology
MH  - *Virus Activation
EDAT- 1999/11/24 09:00
MHDA- 2000/03/21 09:00
CRDT- 1999/11/24 09:00
PHST- 1999/11/24 09:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/11/24 09:00 [entrez]
AID - JID990167 [pii]
AID - 10.1086/315115 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 Dec;180(6):2035-8. doi: 10.1086/315115.