PMID- 10559424
OWN - NLM
STAT- MEDLINE
DCOM- 19991202
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 22
DP  - 1999 Nov 15
TI  - Temporal characteristics of response integration evoked by multiple whisker 
      stimulations in the barrel cortex of rats.
PG  - 10164-75
AB  - We investigated the responses of 114 cells in the barrel cortex of rats to 
      describe the temporal characteristics of excitatory interactions among neurons 
      serving two vibrissae. To examine these interactions, the principal whisker and 
      one adjacent whisker in the same row were stimulated simultaneously or serially 
      at various interstimulus intervals (ISIs). In 37% of the cells tested, combined 
      stimulation of two whiskers exhibited response facilitation; the response to the 
      combined stimulus was larger than the sum of the responses to stimulation of the 
      individual whiskers. The occurrence and magnitude of the facilitation were 
      strongly dependent on the ISI. The ISI capable of producing facilitation for a 
      particular cell was tuned to a narrow range (mean +/- SD, 5.3 +/- 2.3 msec). The 
      ISI that evoked the maximal facilitation was 1.3 +/- 1.3, 3.4 +/- 2.3, and 2.8 
      +/- 4.5 msec for neurons in layers II/III, IV, and V/VI, respectively. These ISIs 
      corresponded to the difference in latencies between the responses to the 
      individual stimulations of the principal and adjacent whiskers. A significant 
      response facilitation was observed in the regular-spiking cells but not in the 
      fast-spiking cells. When the ISI was longer than the range that evoked 
      facilitation, a suppression of the response to the second whisker stimulation was 
      observed. Facilitation was observed predominantly in layer II/III cells (69%) and 
      to a lesser extent in cells of layers IV (15%) and V/VI (24%). Our results 
      suggest that, in the barrel cortex, the temporal relationships among tactile 
      stimuli are coded by facilitatory and inhibitory interactions among neurons 
      located in neighboring barrel columns.
FAU - Shimegi, S
AU  - Shimegi S
AD  - School of Health and Sport Sciences, Osaka University, Toyonaka, Osaka 560-0043, 
      Japan.
FAU - Ichikawa, T
AU  - Ichikawa T
FAU - Akasaki, T
AU  - Akasaki T
FAU - Sato, H
AU  - Sato H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Electric Stimulation
MH  - Electrophysiology/methods
MH  - Male
MH  - Microelectrodes
MH  - Neurons/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/*physiology
MH  - Somatosensory Cortex/*physiology
MH  - Vibrissae/*innervation
PMC - PMC6782972
EDAT- 1999/11/13 00:00
MHDA- 1999/11/13 00:01
PMCR- 2000/05/15
CRDT- 1999/11/13 00:00
PHST- 1999/11/13 00:00 [pubmed]
PHST- 1999/11/13 00:01 [medline]
PHST- 1999/11/13 00:00 [entrez]
PHST- 2000/05/15 00:00 [pmc-release]
AID - 3637 [pii]
AID - 10.1523/JNEUROSCI.19-22-10164.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Nov 15;19(22):10164-75. doi: 10.1523/JNEUROSCI.19-22-10164.1999.