PMID- 10559506
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 147
IP  - 2
DP  - 1999 Dec
TI  - Chemokines and atherosclerosis.
PG  - 213-25
AB  - Chemokines or chemotactic cytokines represent an expanding family of structurally 
      related small molecular weight proteins, recognised as being responsible for 
      leukocyte trafficking and activation. Soon after the discovery of this class of 
      cytokines, about a decade ago, monocyte chemoattractant protein-1 (MCP-1) was 
      found to be highly expressed in human atherosclerotic lesions and postulated to 
      be central in monocyte recruitment into the arterial wall and developing lesions. 
      In this review, we will discuss our present knowledge about MCP-1 and its 
      receptor CCR2 and their role in atherogenesis. Although less well established, 
      other chemokines such as RANTES, MIP-1alpha and MIP-1beta have also been 
      implicated in atherosclerotic lesion formation as are a number of more recently 
      discovered chemokines like MCP-4, ELC and PARC. The role of these chemokines in 
      the progression of atherosclerosis will be discussed as well as the emerging role 
      of IL-8, mostly know for its effects on neutrophils. Particular attention will be 
      given not only to the involvement of chemokines in the inflammatory recruitment 
      of monocytes/macrophages, but also to their role in the related local immune 
      responses and vascular remodelling which occur during the formation of unstable 
      atherosclerotic plaques.
FAU - Reape, T J
AU  - Reape TJ
AD  - Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, New Frontiers 
      Science Park North, Coldharbour Road, Harlow, UK. theresa_reape1@sbphrd.com
FAU - Groot, P H
AU  - Groot PH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Chemokines)
SB  - IM
MH  - Animals
MH  - Arteriosclerosis/immunology/*physiopathology
MH  - Chemokines/*metabolism
MH  - Endothelium, Vascular/metabolism
MH  - Humans
MH  - Macrophages/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - T-Lymphocytes/immunology
RF  - 130
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0021-9150(99)00346-9 [pii]
AID - 10.1016/s0021-9150(99)00346-9 [doi]
PST - ppublish
SO  - Atherosclerosis. 1999 Dec;147(2):213-25. doi: 10.1016/s0021-9150(99)00346-9.