PMID- 10560491
OWN - NLM
STAT- MEDLINE
DCOM- 19991124
LR  - 20161020
IS  - 0884-6812 (Linking)
VI  - 21
IP  - 3
DP  - 1999 Jun
TI  - Mean weighted nuclear volumes in colonic adenocarcinomas. Evaluation of 
      prognostic significance.
PG  - 194-200
AB  - OBJECTIVE: To investigate the correlation of stereologically estimated mean 
      weighted nuclear volumes of tumor cell nuclei (MWNV) with other prognostic 
      factors and survival in colonic adenocarcinomas. STUDY DESIGN: The study group 
      consisted of 42 patients with colonic adenocarcinomas who were treated by a 
      standardized protocol and had a mean follow-up of 89 months. The point sample 
      intercepts method was used to estimate MWNV. In addition, immunohistochemical 
      expression of p53 and Ki-67 was evaluated semiquantitatively. RESULTS: The 
      calculated nuclear volumes correlated significantly with histologic grading and 
      with the extent of tumor progression (organ confined/nonorgan confined). There 
      was no correlation with p53 expression or proliferative activity determined by 
      MIB-1 positivity. No correlation could be demonstrated with sex, age or clinical 
      outcome of the patients. CONCLUSION: Assessment of MWNV in colonic 
      adenocarcinomas does not provide additional information concerning the clinical 
      course.
FAU - Mairinger, T
AU  - Mairinger T
AD  - Department of Pathology, University of Innsbruck, Austria.
FAU - Happacher, R
AU  - Happacher R
FAU - Gabl, C
AU  - Gabl C
FAU - Hoffmann, Y
AU  - Hoffmann Y
FAU - Ofner, D
AU  - Ofner D
FAU - Schmid, K W
AU  - Schmid KW
FAU - Gschwendtner, A
AU  - Gschwendtner A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Anal Quant Cytol Histol
JT  - Analytical and quantitative cytology and histology
JID - 8506819
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adenocarcinoma/chemistry/mortality/*pathology
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Division
MH  - Cell Nucleus/chemistry/*pathology
MH  - Colonic Neoplasms/chemistry/mortality/*pathology
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Humans
MH  - Image Cytometry
MH  - Image Processing, Computer-Assisted
MH  - Karyometry
MH  - Ki-67 Antigen/analysis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Regression Analysis
MH  - Survival Rate
MH  - Tumor Suppressor Protein p53/analysis
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
PST - ppublish
SO  - Anal Quant Cytol Histol. 1999 Jun;21(3):194-200.