PMID- 10561502
OWN - NLM
STAT- MEDLINE
DCOM- 19991214
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 461
IP  - 1-2
DP  - 1999 Nov 12
TI  - FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.
PG  - 91-5
AB  - Frontal temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) is 
      caused by splice site and missense mutations in the tau gene, and characterized 
      by the accumulation of filamentous tau in cerebral neurons and glia. The missense 
      mutations reduce the ability of tau to promote microtubule assembly and increase 
      the ability of tau to form filaments. In this report we demonstrate that mutants 
      V337M and R406W are less susceptible than mutant P301L or corresponding wild type 
      tau to degradation by calpain I. The differences were at least in part due to 
      changes in accessibility of a cleavage site located about 100 amino acids off the 
      carboxy-terminus. The results suggest that the pathogenesis of some forms of 
      FTDP-17 may involve tau accumulation due to decreased proteolytic degradation.
FAU - Yen, S
AU  - Yen S
AD  - Department of Pharmacology, Birdsall Medical Research Building, Mayo Clinic 
      Jacksonville, FL 32224, USA.
FAU - Easson, C
AU  - Easson C
FAU - Nacharaju, P
AU  - Nacharaju P
FAU - Hutton, M
AU  - Hutton M
FAU - Yen, S H
AU  - Yen SH
LA  - eng
GR  - AG17216/AG/NIA NIH HHS/United States
GR  - NS37143/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Recombinant Proteins)
RN  - 0 (tau Proteins)
RN  - EC 3.4.22.- (Calpain)
SB  - IM
MH  - Calpain/*metabolism
MH  - *Chromosomes, Human, Pair 17
MH  - Dementia/*genetics
MH  - Frontal Lobe/*pathology
MH  - Humans
MH  - Immunoblotting
MH  - Kinetics
MH  - Mutation
MH  - Parkinsonian Disorders/*genetics
MH  - Recombinant Proteins/metabolism
MH  - Silver Staining
MH  - Time Factors
MH  - tau Proteins/*genetics
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0014-5793(99)01427-1 [pii]
AID - 10.1016/s0014-5793(99)01427-1 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Nov 12;461(1-2):91-5. doi: 10.1016/s0014-5793(99)01427-1.