PMID- 10564819
OWN - NLM
STAT- MEDLINE
DCOM- 20000111
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 240
IP  - 1
DP  - 1999 Nov 15
TI  - Molecular analyses of the possible RNA-binding protein gene located in the human 
      leukocyte antigen (HLA)--DR subregion.
PG  - 125-32
AB  - We have previously found the sequence having potential for encoding a new protein 
      in the human leukocyte antigen (HLA) class II region. The predicted amino acid 
      sequence showed a significant sequence homology to the Xenopus double-stranded 
      RNA-binding protein (Xlrbp) and the human cellular protein bound to the 
      transactivation response (TAR) of human immunodeficiency virus type-1 (HIV-1) RNA 
      (TRBP). Reverse transcription-polymerase chain reaction (RT-PCR) with poly(A)(+) 
      RNA prepared from human peripheral lymphocytes and direct sequencing analyses in 
      this study showed that the transcripts of the gene encoding the putative 
      RNA-binding protein occurred in human cells: the gene was provisionally named 
      Homo sapiens RNA-binding protein (hsRBP). From the result of Southern blot 
      analyses, it appears that multiple copies of hsRBP are present in the human 
      genome. Together with the known cDNAs having a high sequence homology to hsRBP, 
      the data presented here suggest that the multigene family of the double-stranded 
      RNA-binding protein exists in the human genome.
FAU - Chida, S
AU  - Chida S
AD  - Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 
      Tokyo, Japan.
FAU - Hohjoh, H
AU  - Hohjoh H
FAU - Tokunaga, K
AU  - Tokunaga K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Blotting, Southern
MH  - DNA/chemistry/*genetics
MH  - Gene Dosage
MH  - Gene Expression Regulation
MH  - Genome, Human
MH  - HLA-DR Antigens/*genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Lymphocytes/cytology/metabolism
MH  - Molecular Sequence Data
MH  - Multigene Family/genetics
MH  - Protein Biosynthesis
MH  - RNA/genetics
MH  - RNA, Messenger/genetics
MH  - RNA-Binding Proteins/*genetics/physiology
MH  - Sequence Alignment
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Transcription, Genetic
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0378-1119(99)00422-9 [pii]
AID - 10.1016/s0378-1119(99)00422-9 [doi]
PST - ppublish
SO  - Gene. 1999 Nov 15;240(1):125-32. doi: 10.1016/s0378-1119(99)00422-9.