PMID- 10565556
OWN - NLM
STAT- MEDLINE
DCOM- 19991202
LR  - 20191103
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 10
IP  - 3
DP  - 1999 Aug
TI  - Latex type I sensitization and allergy in children with atopic dermatitis. 
      Evaluation of cross-reactivity to some foods.
PG  - 160-7
AB  - Recent studies have demonstrated that allergy to natural rubber latex (NRL) is 
      associated with cross-reactivity to certain foods. The aim of this study was to 
      investigate the prevalence of NRL sensitization and allergy in children with 
      atopic dermatitis (n=74). We also examined cross-reactions between latex and 
      foods, and compared the frequency of suspected latex cross-reacting fruits in 
      children with and without NRL-specific immunoglobulin E (IgE). Twelve of the 74 
      atopic children studied (16.2%; 95% confidence interval (CI), 8.7-26.6%) had 
      circulating IgE antibodies to latex. These NRL-sensitized children were older and 
      they showed significantly higher total IgE values (p<0.003) when compared with 
      the group of children without NRL sensitization. Of the specific food IgE 
      evaluations, 18.4% (93 out of 505) were positive, and 69.9% were observed in the 
      group of children with latex-specific IgE, most frequently to potato, tomato, 
      sweet pepper, and avocado. An isolated latex-specific IgE response without 
      food-specific IgE was never observed. Exclusively in the latex-positive group, 
      conformity with the report of allergic symptoms after ingestion of food and 
      increased food-specific IgE was found. Twenty children without proven latex 
      sensitization showed increased food-specific IgE, most frequently to potato, 
      banana, and chestnut. Avocado-specific IgE was never determined in this patient 
      group. No significant differences were detected concerning the sensitization to 
      potato, banana, and kiwi between NRL-sensitized children and the group of 20 
      children without latex-specific IgE. The competitive CAP inhibition using sera 
      from children with specific IgE to both latex and food showed different 
      cross-reactivities between latex and the specific food. A close relationship 
      existed between latex and avocado (median inhibition: 100%), whereas 
      sensitization to latex and kiwi seemed to be independent in our study group 
      (inhibition: <25%). In particular, for potato, cross-reactivity and 
      co-sensitization existed. Our study demonstrated that children with atopic 
      dermatitis are a high-risk group for latex sensitization. Increasing age, 
      additional sensitization to ubiquitous inhaled allergens, and enhanced total 
      serum IgE values seemed to be important variables for latex sensitization and 
      further sensitization to the latex-associated foods. Cross-reactivity and, in 
      some cases, co-sensitization to specific fruits and vegetables, were observed.
FAU - Tucke, J
AU  - Tucke J
AD  - Research Institute for Occupational Medicine (BGFA), Institute at the 
      Ruhr-University, Bochum, Germany.
FAU - Posch, A
AU  - Posch A
FAU - Baur, X
AU  - Baur X
FAU - Rieger, C
AU  - Rieger C
FAU - Raulf-Heimsoth, M
AU  - Raulf-Heimsoth M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Antibody Specificity
MH  - Antigens/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Cross Reactions
MH  - Dermatitis, Atopic/epidemiology/*immunology
MH  - Female
MH  - Food Hypersensitivity/epidemiology/*immunology
MH  - Fruit/immunology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Latex Hypersensitivity/epidemiology/*immunology
MH  - Longitudinal Studies
MH  - Male
MH  - Prevalence
MH  - Risk Factors
MH  - Vegetables/immunology
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - 10.1034/j.1399-3038.1999.00013.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 1999 Aug;10(3):160-7. doi: 
      10.1034/j.1399-3038.1999.00013.x.