PMID- 10566707
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20131121
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 94
IP  - 11
DP  - 1999 Nov
TI  - Effect of sumatriptan, a 5HT1 agonist, on the frequency of transient lower 
      esophageal sphincter relaxations and gastroesophageal reflux in healthy subjects.
PG  - 3158-64
AB  - OBJECTIVE: Meals increase the rate of transient lower esophageal sphincter (LES) 
      relaxations, in part by gastric distension. The 5HT1 agonist sumatriptan reduces 
      fasting fundic tone, prolongs the meal-induced fundic relaxation, and delays 
      gastric emptying. We therefore hypothesized that sumatriptan might have a 
      significant effect on the rate of postprandial transient LES relaxations and 
      gastroesophageal reflux. We aimed to study the effect of sumatriptan on 
      postprandial transient LES relaxations and reflux in healthy subjects. METHODS: 
      Esophageal manometry and pH monitoring were performed in 13 healthy volunteers 
      for 30 min before and 90 min after a semiliquid meal (790 kcal). Sumatriptan 6 mg 
      subcutaneous (s.c.) or s.c. placebo were administered on separate days 30 min 
      after the meal. RESULTS: Sumatriptan significantly increased postprandial LES 
      pressure from 11.0 +/- 1.2 mm Hg to 17.6 +/- 1.2 mm Hg (p < 0.05). However, 
      reflux events were not diminished. In the contrary, reflux was more frequent 
      after sumatriptan than after placebo (3 [1.5-4.5]/30 min vs 2 [0-3]/30 min, p < 
      0.05). Transient LES relaxations were more frequent after sumatriptan, 
      particularly in the second 30-min period after drug administration (3 [2.5-5]/30 
      min vs 2 [1.5-2]/30 min, p < 0.05). CONCLUSIONS: Sumatriptan prevents the natural 
      decay in rate of transient LES relaxations that occurs after a meal and favors 
      the occurrence of gastroesophageal reflux despite increasing LES pressure. The 
      sustained postprandial high rate of transient LES relaxations after sumatriptan 
      may be a consequence of a prolonged fundus relaxation and retention of meal in 
      the proximal stomach.
FAU - Sifrim, D
AU  - Sifrim D
AD  - Centre for Gastroenterological Research, University of Leuven, Belgium.
FAU - Holloway, R H
AU  - Holloway RH
FAU - Tack, J
AU  - Tack J
FAU - Zelter, A
AU  - Zelter A
FAU - Missotten, T
AU  - Missotten T
FAU - Coulie, B
AU  - Coulie B
FAU - Janssens, J
AU  - Janssens J
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Placebos)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 8R78F6L9VO (Sumatriptan)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Eating/physiology
MH  - Esophagogastric Junction/*drug effects
MH  - Female
MH  - Gastric Emptying/drug effects/physiology
MH  - Gastric Fundus/drug effects/physiopathology
MH  - Gastroesophageal Reflux/*drug therapy/physiopathology
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Injections, Subcutaneous
MH  - Male
MH  - Muscle Relaxation/drug effects
MH  - Placebos
MH  - Pressure
MH  - Serotonin Receptor Agonists/administration & dosage/*therapeutic use
MH  - Single-Blind Method
MH  - Stomach/drug effects/physiopathology
MH  - Sumatriptan/administration & dosage/*therapeutic use
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0002-9270(99)00568-7 [pii]
AID - 10.1111/j.1572-0241.1999.01509.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 1999 Nov;94(11):3158-64. doi: 
      10.1111/j.1572-0241.1999.01509.x.