PMID- 10566880
OWN - NLM
STAT- MEDLINE
DCOM- 19991202
LR  - 20190831
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 37
IP  - 11
DP  - 1999 Nov
TI  - Assessment of the developmental toxicity and placental transfer of 
      1,2-diethylbenzene in rats.
PG  - 1089-96
AB  - Sprague-Dawley rats were administered 1,2-diethylbenzene (1,2-DEB) by gavage on 
      gestational days (GD) 6 through 20 at dose levels of 0 (corn oil), 5, 15, 25 or 
      35 mg/kg. The dams were euthanized on GD21 and the offspring were weighed and 
      examined for external, visceral and skeletal alterations. Maternal toxicity, 
      indicated by significant decreases in body weight gain and food consumption, was 
      observed at doses of 15 mg/kg and above. Developmental toxicity, expressed as 
      significantly reduced foetal body weights, was seen at doses of 15 mg/kg and 
      higher. There was no evidence of embryolethal or teratogenic effects at any dose 
      tested. The placental transfer of 1,2-DEB was examined after a single oral dose 
      of 25 mg [14C]1,2-DEB/kg on GD18. Maternal and foetal tissues were collected at 
      intervals from 1 to 48 hours. Placental and foetal tissues accounted for less 
      than 0.35% of the administered dose. Levels of radiocarbon in foetuses were lower 
      than those in maternal plasma and placenta at all time points. Analysis performed 
      at 1, 2 and 4 hours indicated that ethyl acetate extractable (acidic) metabolites 
      were predominant in the maternal plasma while n-hexane extractable (neutral) 
      compounds represented the major part of radioactivity in the placenta and foetus. 
      In conclusion, this study demonstrated that 1,2-DEB causes mild foetotoxicity at 
      maternal toxic doses and that the exposure of the developing rat foetus to 
      1,2-DEB and/or metabolites after maternal administration of 1,2-DEB in late 
      gestation is small.
FAU - Saillenfait, A M
AU  - Saillenfait AM
AD  - Institut National de Recherche et de Securite, Vandoeuvre, France.
FAU - Payan, J P
AU  - Payan JP
FAU - Langonne, I
AU  - Langonne I
FAU - Gallissot, F
AU  - Gallissot F
FAU - Sabate, J P
AU  - Sabate JP
FAU - Beydon, D
AU  - Beydon D
FAU - Fabry, J P
AU  - Fabry JP
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Benzene Derivatives)
RN  - 25HOX6T1LU (1,2-diethylbenzene)
SB  - IM
MH  - Abnormalities, Drug-Induced/etiology/metabolism
MH  - Administration, Oral
MH  - Animals
MH  - Benzene Derivatives/administration & dosage/*pharmacokinetics/*toxicity
MH  - Biological Transport
MH  - Eating/drug effects
MH  - Embryonic and Fetal Development/*drug effects
MH  - Female
MH  - Intestinal Absorption
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Placenta/metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Weight Gain/drug effects
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - S0278-6915(99)00105-2 [pii]
AID - 10.1016/s0278-6915(99)00105-2 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 1999 Nov;37(11):1089-96. doi: 10.1016/s0278-6915(99)00105-2.