PMID- 10566968
OWN - NLM
STAT- MEDLINE
DCOM- 19991130
LR  - 20061115
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 19
IP  - 11
DP  - 1999 Nov
TI  - Evidence for neuroprotective effects of endogenous brain-derived neurotrophic 
      factor after global forebrain ischemia in rats.
PG  - 1220-8
AB  - The levels of brain-derived neurotrophic factor (BDNF) vary between different 
      forebrain areas and show region-specific changes after cerebral ischemia. The 
      present study explores the possibility that the levels of endogenous BDNF 
      determine the susceptibility to ischemic neuronal death. To block BDNF activity 
      the authors used the TrkB-Fc fusion protein, which was infused intraventricularly 
      in rats during 1 week before and 1 week after 5 or 30 minutes of global forebrain 
      ischemia. Ischemic damage was quantified in the striatum and hippocampal 
      formation after 1 week of reperfusion using immunocytochemistry and stereological 
      procedures. After the 30-minute insult, there was a significantly lower number of 
      surviving CA4 pyramidal neurons, neuropeptide Y-immunoreactive dentate hilar 
      neurons, and choline acetyltransferase- and TrkA-positive, cholinergic striatal 
      interneurons in the TrkB-Fc-infused rats as compared to controls. In contrast, 
      the TrkB-Fc treatment did not influence survival of CA1 or CA3 pyramidal neurons 
      or striatal projection neurons. Also, after the mild ischemic insult (5 minutes), 
      neuronal death in the CA1 region was similar in the TrkB-Fc-treated and control 
      groups. These results indicate that endogenous BDNF can protect certain neuronal 
      populations against ischemic damage. It is conceivable, though, that efficient 
      neuroprotection after brain insults is dependent not only on this factor but on 
      the concerted action of a large number of neurotrophic molecules.
FAU - Larsson, E
AU  - Larsson E
AD  - Section of Restorative Neurology, Wallenberg Neuroscience Center, University 
      Hospital, Lund, Sweden.
FAU - Nanobashvili, A
AU  - Nanobashvili A
FAU - Kokaia, Z
AU  - Kokaia Z
FAU - Lindvall, O
AU  - Lindvall O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Recombinant Fusion Proteins)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/*metabolism
MH  - Cell Death
MH  - Male
MH  - Prosencephalon/*blood supply
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Ciliary Neurotrophic Factor/genetics/metabolism
MH  - Recombinant Fusion Proteins/pharmacology
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - 10.1097/00004647-199911000-00006 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 1999 Nov;19(11):1220-8. doi: 
      10.1097/00004647-199911000-00006.