PMID- 10567500
OWN - NLM
STAT- MEDLINE
DCOM- 19991229
LR  - 20191210
IS  - 0022-3050 (Print)
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 67
IP  - 6
DP  - 1999 Dec
TI  - Human herpesvirus 6 in cerebrospinal fluid of patients infected with HIV: 
      frequency and clinical significance.
PG  - 789-92
AB  - The objective was to evaluate the frequency of human herpesvirus 6 (HHV-6) DNA 
      detection in the CSF of patients infected with HIV and its relation to brain 
      disease and systemic HHV-6 infection. Nested polymerase chain reaction (PCR) was 
      used to analyse CSF samples from 365 consecutive HIV infected patients with 
      neurological symptoms. When available, plasma and brain tissues from patients 
      whose CSF was HHV-6 positive were also studied. HHV-6 was found in the CSF of 
      eight of the 365 patients (2.2%): two had type A and four type B; the HHV-6 
      variant could not be defined in the remaining two. All eight patients had 
      neurological symptoms and signs related to concomitant opportunistic brain 
      diseases, including cytomegalovirus (CMV) encephalitis in five patients whose CSF 
      was also positive for CMV-DNA. Opportunistic infections but no other unexplained 
      lesions were also found in the brain of all of the four patients who underwent 
      neuropathological examination. Both HHV-6 and CMV were also detected in the 
      plasma of respectively five and seven of seven patients whose CSF was HHV-6 
      positive. In conclusion, HHV-6 type A or B DNA was infrequently found in the CSF 
      of HIV infected patients, in association with both CMV brain infection and 
      systemic HHV-6 replication. However, no certain relation between HHV-6 and brain 
      disease was found.
FAU - Bossolasco, S
AU  - Bossolasco S
AD  - Division of Infectious Diseases, San Raffaele Hospital, Via Stamira d'Ancona 20, 
      20127 Milano, Italy.
FAU - Marenzi, R
AU  - Marenzi R
FAU - Dahl, H
AU  - Dahl H
FAU - Vago, L
AU  - Vago L
FAU - Terreni, M R
AU  - Terreni MR
FAU - Broccolo, F
AU  - Broccolo F
FAU - Lazzarin, A
AU  - Lazzarin A
FAU - Linde, A
AU  - Linde A
FAU - Cinque, P
AU  - Cinque P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
SB  - IM
MH  - Adult
MH  - Brain/virology
MH  - Catchment Area, Health
MH  - Child
MH  - Child, Preschool
MH  - Culture Techniques
MH  - Electrophoresis, Agar Gel/methods
MH  - HIV Seropositivity/*epidemiology/genetics
MH  - Herpesviridae Infections/*cerebrospinal fluid/*epidemiology/genetics
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Polymerase Chain Reaction/methods
MH  - Prospective Studies
MH  - Sensitivity and Specificity
PMC - PMC1736681
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
PMCR- 2002/12/01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
PHST- 2002/12/01 00:00 [pmc-release]
AID - 10.1136/jnnp.67.6.789 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 1999 Dec;67(6):789-92. doi: 10.1136/jnnp.67.6.789.