PMID- 10568217
OWN - NLM
STAT- MEDLINE
DCOM- 19991210
LR  - 20051117
IS  - 0393-5264 (Print)
IS  - 0393-5264 (Linking)
VI  - 14
IP  - 3
DP  - 1999 Jul-Sep
TI  - Proinflammatory cytokines in cervicogenic headache.
PG  - 159-62
AB  - Interleukin-1 beta (IL-1 beta) and Tumour Necrosis Factor-alpha (TNF-alpha) exert 
      their multifunctional biological effect by promoting and increasing the molecular 
      events of cellular inflammation. The aim of this study was to find out whether 
      the cytokine pattern of cervicogenic headache (CH) patients tends, like that seen 
      in cluster headache, towards an inflammatory status. Fifteen CH patients, 
      diagnosed according to the 1998 CHISG criteria, were analysed for serum IL-beta 
      (ELISA) and TNF-alpha (bioassay and ELISA) both during the natural course of a 
      painful attack and during a phase of mechanically worsened pain. The control 
      groups consisted of 15 migraine without aura (MWA) patients and 15 historically 
      healthy subjects. The MWA patients were studied both during (MWA-IN) and outside 
      (MWA-OUT) a migraine attack. Higher levels of both IL-1 beta and TNF-alpha were 
      detected in the sera of CH patients than in that of MWA-IN and MWA-OUT and C 
      subjects. A difference also emerged in CH between spontaneous and mechanically 
      worsened pain phases. We conclude that the degree of cytokine production may 
      depend on the different pathophysiological mechanisms at work in MWA and CH.
FAU - Martelletti, P
AU  - Martelletti P
AD  - Department of Clinical Medicine, University La Sapienza, Rome, Italy.
FAU - Stirparo, G
AU  - Stirparo G
FAU - Giacovazzo, M
AU  - Giacovazzo M
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Funct Neurol
JT  - Functional neurology
JID - 8707746
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Headache Disorders/diagnosis/*immunology
MH  - Humans
MH  - Interleukin-1/*blood
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/diagnosis/immunology
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
PST - ppublish
SO  - Funct Neurol. 1999 Jul-Sep;14(3):159-62.