PMID- 10569250
OWN - NLM
STAT- MEDLINE
DCOM- 19991208
LR  - 20131121
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 31
IP  - 9
DP  - 1999 Sep
TI  - Regulation of small intestinal transit by central nervous calcitonin receptor.
PG  - 499-504
AB  - Salmon calcitonin (sCT) suppresses small intestinal transit (SIT) or motility, 
      but the mechanism is not well understood. Bolus s. c. administration of a 
      pharmacologic dose of sCT (140 IU/kg) to mice significantly decreased plasma 
      calcium and phosphorus, and suppressed SIT from 1 to 8 h for plasma calcium and 
      phosphorus or 20 h for SIT (respective maximal effects were seen at 5 h, between 
      2 and 8 h, and between 1 and 5 h). Significant SIT inhibition did not occur at 
      doses smaller than 140 IU/kg. Reverse transcription-polymerase chain reactions 
      and Southern analysis demonstrated high levels of calcitonin receptor mRNA in 
      diencephalon and lung, moderate levels of mRNA in cerebellum, kidney, and muscle, 
      and barely detectable amounts in cerebral cortex and thymus. No message was 
      detectable in duodenum, jejunum, liver, testis, or heart. Specific binding of 
      [125I] sCT was demonstrated in the diencephalon. Intracerebroventricular (i.c.v.) 
      administration of sCT inhibited SIT time- and dose-dependently. Maximal 
      inhibition was obtained at a dose of 4 IU/kg, 20 min after injection. 
      Pretreatment with sCT (140 IU/kg s.c.) completely abolished inhibition of SIT by 
      i.c.v. sCT (4 IU/kg). These results suggest that sCT binds to receptors in the 
      central nervous system and inhibits small bowel transit.
FAU - Hamada, S
AU  - Hamada S
AD  - Department of Biochemistry, Ohu University School of Dentistry, Koriyama, Japan.
FAU - Kawane, T
AU  - Kawane T
FAU - Akeno, N
AU  - Akeno N
FAU - Igarashi, H
AU  - Igarashi H
FAU - Horiuchi, N
AU  - Horiuchi N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Phosphates)
RN  - 0 (Receptors, Calcitonin)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/blood
MH  - Central Nervous System/*physiology
MH  - Down-Regulation
MH  - *Gastrointestinal Transit
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Intestine, Small/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Phosphates/blood
MH  - Receptors, Calcitonin/*physiology
EDAT- 1999/11/24 00:00
MHDA- 1999/11/24 00:01
CRDT- 1999/11/24 00:00
PHST- 1999/11/24 00:00 [pubmed]
PHST- 1999/11/24 00:01 [medline]
PHST- 1999/11/24 00:00 [entrez]
AID - 10.1055/s-2007-978783 [doi]
PST - ppublish
SO  - Horm Metab Res. 1999 Sep;31(9):499-504. doi: 10.1055/s-2007-978783.