PMID- 10570993
OWN - NLM
STAT- MEDLINE
DCOM- 19991202
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 238
IP  - 1
DP  - 1999 Sep 30
TI  - Extensive nucleotide variability within a 370 kb sequence from the central region 
      of the major histocompatibility complex.
PG  - 157-61
AB  - The recent availability of the genomic sequence spanning the central and 
      telomeric end of the major histocompatibility complex (MHC) has allowed a 
      detailed study of its organisation, gene content and level of nucleotide 
      variability. Previous analyses of nucleotide variability in the MHC have focused 
      on the coding regions of the human leukocyte antigen (HLA) Class I and II genes. 
      Non-coding nucleotide variability has been considered a by-product of exonic 
      diversity. However, with the advent of genomic sequencing, the extent of 
      non-coding nucleotide variability within the MHC has just begun to be 
      appreciated. In this study, we compared different human haplotypes in 370 kb of 
      sequence in the central region of the MHC to show the following: 1. unusually 
      high levels of non-coding nucleotide variability, up to 80 times greater than 
      elsewhere in the genome; 2. non-coding nucleotide variability greater than 1% at 
      nucleotide sites distant to the Class I genes; 3. nucleotide variability greater 
      than 1% maintained over regions containing highly linked loci; and 4. distinct 
      troughs and peaks in the level of nucleotide variability. We will discuss these 
      observations in relation to a possible role of nucleotide variability in the 
      organisation of the MHC.
FAU - Gaudieri, S
AU  - Gaudieri S
AD  - Centre for Information Biology, National Institute of Genetics, Mishima, 
      Shizuoka, Japan. sgaudier@lab.nig.ac.jp
FAU - Kulski, J K
AU  - Kulski JK
FAU - Dawkins, R L
AU  - Dawkins RL
FAU - Gojobori, T
AU  - Gojobori T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
SB  - IM
MH  - Chromosome Mapping
MH  - *Genes, MHC Class I
MH  - Genetic Linkage
MH  - *Genetic Variation
MH  - Humans
MH  - Polymorphism, Genetic
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - S0378-1119(99)00255-3 [pii]
AID - 10.1016/s0378-1119(99)00255-3 [doi]
PST - ppublish
SO  - Gene. 1999 Sep 30;238(1):157-61. doi: 10.1016/s0378-1119(99)00255-3.