PMID- 10571233
OWN - NLM
STAT- MEDLINE
DCOM- 19991206
LR  - 20220410
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 24
IP  - 2
DP  - 1999 Oct
TI  - Essential role for TrkB receptors in hippocampus-mediated learning.
PG  - 401-14
AB  - Brain-derived neurotrophic factor (BDNF) and its receptor TrkB regulate both 
      short-term synaptic functions and long-term potentiation (LTP) of brain synapses, 
      raising the possibility that BDNF/TrkB may be involved in cognitive functions. We 
      have generated conditionally gene targeted mice in which the knockout of the trkB 
      gene is restricted to the forebrain and occurs only during postnatal development. 
      Adult mutant mice show increasingly impaired learning behavior or inappropriate 
      coping responses when facing complex and/or stressful learning paradigms but 
      succeed in simple passive avoidance learning. Homozygous mutants show impaired 
      LTP at CA1 hippocampal synapses. Interestingly, heterozygotes show a partial but 
      substantial reduction of LTP but appear behaviorally normal. Thus, CA1 LTP may 
      need to be reduced below a certain threshold before behavioral defects become 
      apparent.
FAU - Minichiello, L
AU  - Minichiello L
AD  - European Molecular Biology Laboratory, Heidelberg, Germany.
FAU - Korte, M
AU  - Korte M
FAU - Wolfer, D
AU  - Wolfer D
FAU - Kuhn, R
AU  - Kuhn R
FAU - Unsicker, K
AU  - Unsicker K
FAU - Cestari, V
AU  - Cestari V
FAU - Rossi-Arnaud, C
AU  - Rossi-Arnaud C
FAU - Lipp, H P
AU  - Lipp HP
FAU - Bonhoeffer, T
AU  - Bonhoeffer T
FAU - Klein, R
AU  - Klein R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Protein Isoforms)
RN  - 059QF0KO0R (Water)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/anatomy & histology/cytology
MH  - Catalysis
MH  - Hippocampus/*physiology
MH  - Learning/*physiology
MH  - Long-Term Potentiation/physiology
MH  - Maze Learning/physiology
MH  - Mice
MH  - Mice, Knockout/genetics
MH  - Protein Isoforms/physiology
MH  - Receptor, trkB/genetics/*physiology
MH  - Reference Values
MH  - Response Elements/physiology
MH  - Synaptic Transmission/physiology
MH  - Water
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - S0896-6273(00)80853-3 [pii]
AID - 10.1016/s0896-6273(00)80853-3 [doi]
PST - ppublish
SO  - Neuron. 1999 Oct;24(2):401-14. doi: 10.1016/s0896-6273(00)80853-3.