PMID- 10571789
OWN - NLM
STAT- MEDLINE
DCOM- 19991210
LR  - 20031114
IS  - 0085-2538 (Print)
IS  - 0085-2538 (Linking)
VI  - 56
IP  - 5
DP  - 1999 Nov
TI  - Bone marrow transplantation attenuates murine IgA nephropathy: role of a stem 
      cell disorder.
PG  - 1809-17
AB  - BACKGROUND: The pathogenesis of IgA nephropathy is still obscure. The aim of this 
      study was to investigate whether the fundamental pathogenesis of IgA nephropathy 
      lies in bone marrow stem cells (BMCs). METHODS: We used donors of two different 
      strains for bone marrow transplantation (BMT) into mice with a high content of 
      serum IgA (ddY strain, HIGA mice), a murine model of IgA nephropathy. One group 
      (B6-->HIGA, N = 5) received BMCs of C57BL/6j (B6) mice, and the other 
      (HIGA-->HIGA, N = 8) were reconstituted with BMCs of HIGA mice. RESULTS: 
      Twenty-six weeks after BMT, in B6-->HIGA mice, mesangial deposits of IgA and C3 
      were statistically milder than those in HIGA-->HIGA mice. Light microscopic 
      observations disclosed that glomerular sclerosis and mesangial matrix expansion 
      in B6-->HIGA mice were decreased compared with those in HIGA-->HIGA mice. These 
      B6-->HIGA mice also excreted less urinary albumin than HIGA-->HIGA mice. 
      Furthermore, serum levels of IgA in B6-->HIGA mice were markedly lower than those 
      in HIGA-->HIGA mice. Size analysis of serum IgA revealed that macromolecular IgA 
      were notably lower in B6-->HIGA mice than in HIGA-->HIGA mice. CONCLUSIONS: Our 
      results suggest that qualitative and quantitative changes of serum IgA are 
      determined at the level of stem cells, and that BMT from normal donors can 
      attenuate glomerular lesions in HIGA mice. This approach may offer a new avenue 
      to study the pathogenesis of IgA nephropathy.
FAU - Imasawa, T
AU  - Imasawa T
AD  - Department of Internal Medicine, Jikei University School of Medicine, Division of 
      Hemodialysis, Saitama, Japan. imayan@jikei.ac.jp
FAU - Nagasawa, R
AU  - Nagasawa R
FAU - Utsunomiya, Y
AU  - Utsunomiya Y
FAU - Kawamura, T
AU  - Kawamura T
FAU - Zhong, Y
AU  - Zhong Y
FAU - Makita, N
AU  - Makita N
FAU - Muso, E
AU  - Muso E
FAU - Miyawaki, S
AU  - Miyawaki S
FAU - Maruyama, N
AU  - Maruyama N
FAU - Hosoya, T
AU  - Hosoya T
FAU - Sakai, O
AU  - Sakai O
FAU - Ohno, T
AU  - Ohno T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Kidney Int
JT  - Kidney international
JID - 0323470
RN  - 0 (Immunoglobulin A)
SB  - IM
CIN - Kidney Int. 1999 Nov;56(5):1964-6. PMID: 10571809
MH  - Age Factors
MH  - Animals
MH  - *Bone Marrow Transplantation
MH  - Female
MH  - Glomerulonephritis, IGA/etiology/*therapy
MH  - Hematopoietic Stem Cells/*physiology
MH  - Immunoglobulin A/blood
MH  - Mice
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - S0085-2538(15)46499-3 [pii]
AID - 10.1046/j.1523-1755.1999.00750.x [doi]
PST - ppublish
SO  - Kidney Int. 1999 Nov;56(5):1809-17. doi: 10.1046/j.1523-1755.1999.00750.x.