PMID- 10571911
OWN - NLM
STAT- MEDLINE
DCOM- 20000211
LR  - 20190910
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 49
IP  - 2
DP  - 2000 Feb
TI  - Metal ion release from titanium with active oxygen species generated by rat 
      macrophages in vitro.
PG  - 238-43
AB  - The release of metal ions due to active oxygen species generated by macrophages 
      (Mphi) phagocytosing high-density polyethylene (HDPE) particles was studied in 
      vitro to investigate the mechanism behind the release of metal ions from titanium 
      implants into nearby tissues in the absence of wear and fretting in vivo. To 
      determine the effects of Mphis on metal ion release, titanium disks were immersed 
      in different solutions and the titanium ions released from the titanium disks 
      into each solution were quantified. The results revealed that active oxygen 
      species generated by Mphis induced the metal ion release. In particular, the ion 
      release was accelerated with HDPE because the Mphis that phagocytosed HDPE 
      generated more active oxygen species than Mphis that did not phagocytose any 
      HDPE. Metal ions were also released by organic species in the absence of Mphis. 
      These are some of the causes for metal ion release from titanium implants in the 
      absence of wear and fretting in vivo.
CI  - Copyright 2000 John Wiley & Sons, Inc.
FAU - Mu, Y
AU  - Mu Y
AD  - Biomaterials Research Team, National Research Institute for Metals, 1-2-1 Sengen, 
      Tsukuba 305-0047, Japan.
FAU - Kobayashi, T
AU  - Kobayashi T
FAU - Sumita, M
AU  - Sumita M
FAU - Yamamoto, A
AU  - Yamamoto A
FAU - Hanawa, T
AU  - Hanawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Biocompatible Materials)
RN  - 0 (Reactive Oxygen Species)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Animals
MH  - *Biocompatible Materials
MH  - Female
MH  - *Macrophages, Peritoneal
MH  - Phagocytosis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Reactive Oxygen Species
MH  - *Titanium
EDAT- 1999/11/26 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/11/26 09:00
PHST- 1999/11/26 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/11/26 09:00 [entrez]
AID - 10.1002/(SICI)1097-4636(200002)49:2<238::AID-JBM12>3.0.CO;2-J [pii]
AID - 10.1002/(sici)1097-4636(200002)49:2<238::aid-jbm12>3.0.co;2-j [doi]
PST - ppublish
SO  - J Biomed Mater Res. 2000 Feb;49(2):238-43. doi: 
      10.1002/(sici)1097-4636(200002)49:2<238::aid-jbm12>3.0.co;2-j.