PMID- 10572913
OWN - NLM
STAT- MEDLINE
DCOM- 20000128
LR  - 20190905
IS  - 0143-3636 (Print)
IS  - 0143-3636 (Linking)
VI  - 20
IP  - 11
DP  - 1999 Nov
TI  - Quantification of 99Tcm-HMPAO brain SPET in two series of healthy volunteers 
      using different triple-headed SPET configurations: normal databases and 
      methodological considerations.
PG  - 1031-40
AB  - We evaluated the methodological issues underlying the assessment of normal 
      confidence intervals, as used in clinically based region-of-interest (ROI) 
      semi-quantification of 99Tcm-HMPAO brain SPET. At two different centres equipped 
      with high-resolution, triple-headed gamma cameras, HMPAO SPET scans were 
      performed on two groups of 24 and 15 healthy volunteers respectively. Together 
      with an operator-defined analysis (ODA), a semi-automated analysis (SAA) was 
      conducted on the normal datasets in one centre. Tests of intra- and 
      inter-observer variability were performed. Repeat scans were performed within 72 
      h after the first to analyse short-term regional inter-study variations. The 
      overall regional uptake showed significant differences in most regions between 
      both normal datasets. Intra-observer and inter-observer reproducibility were on 
      average within 4% for the ODA, while for the SAA it was less than 1%. Inter-study 
      variations were excellent for both centres, ranging from -4% to +3% for most 
      regions studied. The variability in clinical brain perfusion studies largely 
      depends on the reproducibility of the data analysis technique. A semi-automated 
      approach shows clear advantages over an entirely operator-defined approach. 
      Intra-subject repeat studies show enough stability for use as reliable baseline 
      measurements in the construction of a normal database or to allow activation 
      studies with high sensitivity.
FAU - Van Laere, K
AU  - Van Laere K
AD  - Division of Nuclear Medicine, University Hospital, Ghent, Belgium. 
      koen.vanlaere@rug.ac.be
FAU - De Sadeleer, C
AU  - De Sadeleer C
FAU - Dobbeleir, A
AU  - Dobbeleir A
FAU - Bossuyt, A
AU  - Bossuyt A
FAU - De Deyn, P
AU  - De Deyn P
FAU - Dierckx, R
AU  - Dierckx R
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nucl Med Commun
JT  - Nuclear medicine communications
JID - 8201017
RN  - 0 (Radiopharmaceuticals)
RN  - 3B744AG22N (Technetium Tc 99m Exametazime)
SB  - IM
MH  - Adult
MH  - Aging/physiology
MH  - Brain/*diagnostic imaging
MH  - Databases, Factual
MH  - Evaluation Studies as Topic
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - *Radiopharmaceuticals
MH  - Reproducibility of Results
MH  - Sex Characteristics
MH  - *Technetium Tc 99m Exametazime
MH  - Tomography, Emission-Computed, Single-Photon/*methods/standards
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - 10.1097/00006231-199911000-00008 [doi]
PST - ppublish
SO  - Nucl Med Commun. 1999 Nov;20(11):1031-40. doi: 10.1097/00006231-199911000-00008.