PMID- 10573679
OWN - NLM
STAT- MEDLINE
DCOM- 19991207
LR  - 20131121
IS  - 0190-535X (Print)
IS  - 0190-535X (Linking)
VI  - 26
IP  - 10
DP  - 1999 Nov-Dec
TI  - Management of thromboembolism in patients with cancer.
PG  - 1625-32; quiz 1633-4
AB  - PURPOSE/OBJECTIVES: To review the phenomenon of thromboembolism in patients with 
      cancer, discuss treatment options for deep vein thrombosis (DVT), and describe 
      oncology nurses' role. DATA SOURCES: Published articles, abstracts, professional 
      communications, drug manufacturer information, and personal clinical experience. 
      DATA SYNTHESIS: The incidence of DVT in patients with cancer can be as high as 
      15%. The cause of thromboembolism is multifactorial and includes tumor type, 
      alterations in coagulation, specific chemotherapy agents, and clinical 
      considerations. Although these patients traditionally have been treated with 
      standard unfractionated heparin (UFH) therapy, low molecular weight heparin 
      (LMWH) has been studied extensively and is an acceptable alternative treatment. 
      LMWH should be followed by a period of oral anticoagulants, although some 
      patients may benefit from long-term heparin therapy. Oncology nurses are 
      qualified to identify patients who are at risk for DVT and, in expanded roles, 
      may manage patients on anticoagulant therapy successfully. CONCLUSIONS: LMWH 
      followed by a course of oral anticoagulant therapy is an alternative way to treat 
      DVT. Treatment with LMWH is less expensive than traditional UFH and has a 
      preferred side effect profile. IMPLICATIONS FOR NURSING PRACTICE: All oncology 
      nurses should be aware of the different risk factors for DVT in patients with 
      cancer and current clinical management should DVT occur. Oncology nurses in 
      expanded roles or advanced practice nurses may choose to manage DVT with LMWH 
      followed by oral anticoagulant therapy. Some patients may require long-term 
      treatment with heparin therapy rather than oral anticoagulants.
FAU - Viale, P H
AU  - Viale PH
AD  - Santa Clara Valley Health and Hospital System, San Jose, CA, USA. PGViale@aol.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Oncol Nurs Forum
JT  - Oncology nursing forum
JID - 7809033
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 5Q7ZVV76EI (Warfarin)
SB  - IM
CIN - Oncol Nurs Forum. 2000 Apr;27(3):426-7. PMID: 10785896
MH  - Anticoagulants/therapeutic use
MH  - Heparin, Low-Molecular-Weight/therapeutic use
MH  - Humans
MH  - Neoplasms/*complications/nursing
MH  - Oncology Nursing/methods
MH  - Thromboembolism/diagnosis/*drug therapy/etiology
MH  - Venous Thrombosis/diagnosis/*drug therapy/etiology
MH  - Warfarin/therapeutic use
RF  - 47
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
PST - ppublish
SO  - Oncol Nurs Forum. 1999 Nov-Dec;26(10):1625-32; quiz 1633-4.