PMID- 10574242
OWN - NLM
STAT- MEDLINE
DCOM- 19991202
LR  - 20181113
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 81
IP  - 4
DP  - 1999 Oct
TI  - Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal 
      tumour-Ewing's group.
PG  - 586-91
AB  - Esthesioneuroblastoma (ENB) is a rare, site-specific, locally aggressive neuronal 
      malignancy so far thought to belong to primitive peripheral neuroectodermal 
      tumour-Ewing's tumour (pPNETs-ETs). Its anatomical location, in addition to 
      morphologic, immunophenotypic and ultrastructural features, suggests its origin 
      in the neuronal or neuroendocrine cells of the olfactory epithelium. However, the 
      cytogenetic and molecular data currently available appear controversial on the 
      presence of the typical translocation t(11;22)(q24;q12) and of trisomy 8, 
      chromosomal changes that characterize the tumours belonging to the pPNETs-ETs. 
      Herein we have analysed five ENB tumour specimens for trisomy 8 by fluorescence 
      in situ hybridization (FISH), for the presence of EWS gene rearrangements by 
      FISH, reverse transcription polymerase chain reaction and Southern blot analyses, 
      as well as for the expression of the Ewing sarcoma-associated MIC2 antigen by 
      immunohistochemistry. Neither EWS/FLI-I, EWS/ERG and EWS/FEV fusion genes nor 
      MIC2 expression were found in any tumour, whereas trisomy 8 was found in one case 
      only. Moreover, DNA from three cases analysed by Southern blot did not show EWS 
      gene rearrangements. Our results support the evidence that ENB is not a member of 
      the pPNETs-ETs.
FAU - Mezzelani, A
AU  - Mezzelani A
AD  - Division of Pathology and Cytology, Istituto Nazionale per lo Studio e la Cura 
      dei Tumori, Milan, Italy.
FAU - Tornielli, S
AU  - Tornielli S
FAU - Minoletti, F
AU  - Minoletti F
FAU - Pierotti, M A
AU  - Pierotti MA
FAU - Sozzi, G
AU  - Sozzi G
FAU - Pilotti, S
AU  - Pilotti S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Heterogeneous-Nuclear Ribonucleoproteins)
RN  - 0 (RNA-Binding Protein EWS)
RN  - 0 (Ribonucleoproteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosome Aberrations
MH  - Esthesioneuroblastoma, Olfactory/chemistry/*classification/genetics
MH  - Female
MH  - Heterogeneous-Nuclear Ribonucleoproteins
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Middle Aged
MH  - Neuroectodermal Tumors, Primitive, Peripheral/*classification
MH  - RNA-Binding Protein EWS
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Ribonucleoproteins/genetics
PMC - PMC2362903
EDAT- 1999/11/26 00:00
MHDA- 1999/11/26 00:01
CRDT- 1999/11/26 00:00
PHST- 1999/11/26 00:00 [pubmed]
PHST- 1999/11/26 00:01 [medline]
PHST- 1999/11/26 00:00 [entrez]
AID - 6690734 [pii]
AID - 10.1038/sj.bjc.6690734 [doi]
PST - ppublish
SO  - Br J Cancer. 1999 Oct;81(4):586-91. doi: 10.1038/sj.bjc.6690734.