PMID- 10575198
OWN - NLM
STAT- MEDLINE
DCOM- 20000508
LR  - 20190212
IS  - 1015-8987 (Print)
IS  - 1015-8987 (Linking)
VI  - 9
IP  - 4-5
DP  - 1999
TI  - Biophysical properties and molecular basis of cardiac rapid and slow delayed 
      rectifier potassium channels.
PG  - 201-16
AB  - Normal cardiac action potential repolarization is dependent on activation of 
      several K(+) currents, including I(Kr) and I(Ks). I(Kr) activates rapidly at 
      positive potentials, exhibits inward rectification caused by C-type inactivation, 
      and is potently blocked by methanesulfon-anilide antiarrhythmic drugs and several 
      other common medications. I(Ks) activates very slowly, does not inactivate and is 
      blocked by some benzodiazepines and a chromanol. HERG encodes subunits that form 
      channels that mediate I(Kr). KVLQT1 and minK encode subunits that coassemble to 
      form channels that mediate I(Ks). Mutations in any of these genes cause long QT 
      syndrome, a disorder of cardiac repolarization that predisposes individuals to 
      lethal arrhythmias. In this review, we summarize recent studies of the 
      biophysical and pharmacological properties of HERG and KvLQT1/minK K(+) channels.
CI  - Copyright 1999 S. Karger AG, Basel
FAU - Mitcheson, J S
AU  - Mitcheson JS
AD  - Department of Medicine, Division of Cardiology, Eccles Program in Human Molecular 
      Biology and Genetics, University of Utah, Salt Lake City, Utah 84112, USA.
FAU - Sanguinetti, M C
AU  - Sanguinetti MC
LA  - eng
GR  - HL55236/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - 0 (Cation Transport Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (ERG protein, human)
RN  - 0 (ERG1 Potassium Channel)
RN  - 0 (Ether-A-Go-Go Potassium Channels)
RN  - 0 (KCNH2 protein, human)
RN  - 0 (KCNH6 protein, human)
RN  - 0 (Potassium Channels)
RN  - 0 (Potassium Channels, Voltage-Gated)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcriptional Regulator ERG)
SB  - IM
MH  - Animals
MH  - *Cation Transport Proteins
MH  - *DNA-Binding Proteins
MH  - ERG1 Potassium Channel
MH  - Ether-A-Go-Go Potassium Channels
MH  - Heart/*physiology/physiopathology
MH  - Humans
MH  - Long QT Syndrome/physiopathology
MH  - Potassium Channels/chemistry/genetics/*physiology
MH  - *Potassium Channels, Voltage-Gated
MH  - *Trans-Activators
MH  - Transcriptional Regulator ERG
RF  - 136
EDAT- 1999/11/27 09:00
MHDA- 2000/05/16 09:00
CRDT- 1999/11/27 09:00
PHST- 1999/11/27 09:00 [pubmed]
PHST- 2000/05/16 09:00 [medline]
PHST- 1999/11/27 09:00 [entrez]
AID - 16317 [pii]
AID - 10.1159/000016317 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 1999;9(4-5):201-16. doi: 10.1159/000016317.