PMID- 10575214 OWN - NLM STAT- MEDLINE DCOM- 20000106 LR - 20171101 IS - 0301-0171 (Print) IS - 0301-0171 (Linking) VI - 86 IP - 3-4 DP - 1999 TI - High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. PG - 237-9 AB - Histone deacetylases have been described as crucial cofactors of mammalian transcriptional complexes. We have recently identified human histone deacetylase HDAC3 on chromosome 5q31 by fluorescence in situ hybridization (FISH) in a region commonly deleted in malignant myeloid disease. Since HDAC3 carries strong potential to be a tumor suppressor gene, we report herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband. FAU - Mahlknecht, U AU - Mahlknecht U AD - Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, Manhasset NY, USA. Mahlknecht@em.uni-frankfurt.de FAU - Bucala, R AU - Bucala R FAU - Hoelzer, D AU - Hoelzer D FAU - Verdin, E AU - Verdin E LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Switzerland TA - Cytogenet Cell Genet JT - Cytogenetics and cell genetics JID - 0367735 RN - 0 (Genetic Markers) RN - EC 3.5.1.98 (Histone Deacetylases) RN - EC 3.5.1.98 (histone deacetylase 3) SB - IM MH - Chromosome Mapping MH - *Chromosomes, Human, Pair 5 MH - *Genes, Tumor Suppressor MH - Genetic Markers MH - Histone Deacetylases/*genetics MH - Humans MH - In Situ Hybridization, Fluorescence EDAT- 1999/11/27 00:00 MHDA- 1999/11/27 00:01 CRDT- 1999/11/27 00:00 PHST- 1999/11/27 00:00 [pubmed] PHST- 1999/11/27 00:01 [medline] PHST- 1999/11/27 00:00 [entrez] AID - 15347 [pii] AID - 10.1159/000015347 [doi] PST - ppublish SO - Cytogenet Cell Genet. 1999;86(3-4):237-9. doi: 10.1159/000015347.