PMID- 10576207
OWN - NLM
STAT- MEDLINE
DCOM- 19991207
LR  - 20131121
IS  - 0023-6837 (Print)
IS  - 0023-6837 (Linking)
VI  - 79
IP  - 11
DP  - 1999 Nov
TI  - Trapidil inhibits monocyte chemoattractant protein-1 and macrophage accumulation 
      after balloon arterial injury in rabbits.
PG  - 1369-75
AB  - Trapidil (triazolopyrimidine) is an antiplatelet agent that acts in part as a 
      phosphodiesterase inhibitor and as a competitive inhibitor of the 
      platelet-derived growth factor (PDGF) receptor. Trapidil has been shown to 
      attenuate intimal hyperplasia in rat and hamster models of balloon arterial 
      injury and to inhibit restenosis after percutaneous transluminal coronary 
      angioplasty in several small clinical trials. Monocyte chemoattractant protein-1 
      (MCP-1) is a PDGF-inducible monocyte chemoattractant that is thought to play a 
      particularly important role in recruiting monocyte/macrophages to sites of 
      atherosclerosis and vessel injury. We hypothesized that, because of its ability 
      to antagonize PDGF-mediated events, trapidil would inhibit the synthesis of MCP-1 
      and decrease macrophage accumulation in the injured arterial wall. 
      Hypercholesterolemic rabbits were treated with trapidil (60 mg/kg/day 
      subcutaneously) the day before and then daily for 6 days after balloon injury of 
      the femoral artery; control rabbits received vehicle only. Trapidil resulted in a 
      75% reduction in MCP-1 expression and macrophage accumulation in the arterial 
      wall 7 days after injury. This study suggests that trapidil has potent 
      anti-inflammatory properties and that its activity in attenuating intimal 
      hyperplasia may be in part attributed to its effects on macrophage accumulation.
FAU - Poon, M
AU  - Poon M
AD  - The Cardiovascular Institute, Department of Medicine, Mount Sinai School of 
      Medicine, New York, New York 10029, USA.
FAU - Cohen, J
AU  - Cohen J
FAU - Siddiqui, Z
AU  - Siddiqui Z
FAU - Fallon, J T
AU  - Fallon JT
FAU - Taubman, M B
AU  - Taubman MB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lab Invest
JT  - Laboratory investigation; a journal of technical methods and pathology
JID - 0376617
RN  - 0 (Chemokine CCL2)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - EYG5Y6355E (Trapidil)
SB  - IM
MH  - Animals
MH  - Catheterization/*adverse effects
MH  - Cell Count/drug effects
MH  - Chemokine CCL2/*antagonists & inhibitors/metabolism
MH  - Femoral Artery/*injuries/pathology
MH  - Macrophages/drug effects/*pathology/physiology
MH  - Platelet Aggregation Inhibitors/*pharmacology
MH  - Rabbits
MH  - Trapidil/*pharmacology
MH  - Wounds and Injuries/*metabolism/*pathology
EDAT- 1999/11/27 00:00
MHDA- 1999/11/27 00:01
CRDT- 1999/11/27 00:00
PHST- 1999/11/27 00:00 [pubmed]
PHST- 1999/11/27 00:01 [medline]
PHST- 1999/11/27 00:00 [entrez]
PST - ppublish
SO  - Lab Invest. 1999 Nov;79(11):1369-75.