PMID- 10576504
OWN - NLM
STAT- MEDLINE
DCOM- 19991208
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 23
IP  - 11
DP  - 1999 Nov
TI  - A new complex variant Philadelphia chromosome, t(1;9;22)ins(17;22), characterized 
      by fluorescence in situ hybridization in an adult ALL.
PG  - 1001-6
AB  - A new complex variant Philadelphia chromosome was detected in a 65-year-old man 
      with acute, pre-B, lymphoblastic leukemia (ALL). The classic cytogenetic analysis 
      identified an apparently balanced three-way translocation 
      t(1;9;22)(q25;q34;q11.2). Fluorescence in situ hybridization (FISH) studies 
      confirmed the translocation and showed bcr/abl fusion on the der(22). However, 
      these studies revealed that the distal part of the bcr gene was not translocated 
      onto chromosome 1 at 1q25, but inserted into chromosome 17 at 17p12-13. This 
      complex variant translocation was described as a 
      t(1;9;22)(q25;q34;q11.2)ins(17;22)(p12-13;q11.2q11.2). Secondary changes 
      including +8, an inversion of the derivative chromosome 9, a translocation 
      t(14;20)(q11;q13), and an additional derivative 22 were also identified in most 
      of the abnormal cells. The patient died from systemic fungemia and multiorgan 
      failure 9 months after the diagnosis of ALL. The clinical significance of complex 
      variant Philadelphia chromosomes in ALL is reviewed and discussed.
FAU - Fan, Y S
AU  - Fan YS
AD  - Department of Laboratory Medicine, London Health Sciences Centre, Ont., Canada. 
      fany@lhsc.on.ca
FAU - Rizkalla, K
AU  - Rizkalla K
FAU - Barr, R M
AU  - Barr RM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosome Banding
MH  - *Chromosomes, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - *Philadelphia Chromosome
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 1999/11/27 00:00
MHDA- 1999/11/27 00:01
CRDT- 1999/11/27 00:00
PHST- 1999/11/27 00:00 [pubmed]
PHST- 1999/11/27 00:01 [medline]
PHST- 1999/11/27 00:00 [entrez]
AID - S0145-2126(99)00130-7 [pii]
AID - 10.1016/s0145-2126(99)00130-7 [doi]
PST - ppublish
SO  - Leuk Res. 1999 Nov;23(11):1001-6. doi: 10.1016/s0145-2126(99)00130-7.