PMID- 10576509
OWN - NLM
STAT- MEDLINE
DCOM- 19991208
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 23
IP  - 11
DP  - 1999 Nov
TI  - p53 gene deletion and trisomy 12 in hairy cell leukemia and its variant.
PG  - 1041-5
AB  - The deletion or mutation of the p53 tumour suppressor gene on chromosome 17p13 is 
      known to be associated with aggressive disease in several B-cell malignancies. 
      The present study describes the p53 gene status in 20 cases of hairy cell 
      leukemia (HCL) and in 12 cases of its morphological variant (HCL-V) by 
      fluorescence in situ hybridization (FISH). A high incidence of p53 deletion was 
      found in both diseases (75-100% of cases). However, a significant difference was 
      observed between the proportion of cells with p53 deletion in HCL-V cases (mean 
      31%) and HCL cases (mean 12%) P value < 0.01. The observed difference correlates 
      with the well known tendency for transformation and poor response to therapy in 
      HCL-V and seven cases of HCL-V with greater than 22% of cells with p53 deletion 
      showed features of disease progression and transformation. Trisomy 12 was present 
      in 8.5% of the cells in one case of HCL-V and in 6-8% of cells in three cases of 
      HCL.
FAU - Vallianatou, K
AU  - Vallianatou K
AD  - Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital NHS 
      Trust/Institute of Cancer Research, London, UK.
FAU - Brito-Babapulle, V
AU  - Brito-Babapulle V
FAU - Matutes, E
AU  - Matutes E
FAU - Atkinson, S
AU  - Atkinson S
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
SB  - IM
MH  - Alleles
MH  - *Chromosomes, Human, Pair 12
MH  - Female
MH  - *Gene Deletion
MH  - *Genes, p53
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Hairy Cell/*genetics
MH  - Male
MH  - *Trisomy
EDAT- 1999/11/27 00:00
MHDA- 1999/11/27 00:01
CRDT- 1999/11/27 00:00
PHST- 1999/11/27 00:00 [pubmed]
PHST- 1999/11/27 00:01 [medline]
PHST- 1999/11/27 00:00 [entrez]
AID - S0145-2126(99)00127-7 [pii]
AID - 10.1016/s0145-2126(99)00127-7 [doi]
PST - ppublish
SO  - Leuk Res. 1999 Nov;23(11):1041-5. doi: 10.1016/s0145-2126(99)00127-7.