PMID- 10578102
OWN - NLM
STAT- MEDLINE
DCOM- 20000105
LR  - 20190905
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 416
IP  - 1
DP  - 2000 Jan 3
TI  - Induction of c-fos-like and fosB-like immunoreactivity reveals forebrain neuronal 
      populations involved differentially in pup-mediated maternal behavior in juvenile 
      and adult rats.
PG  - 45-78
AB  - Juvenile rats can exhibit maternal behavior after being exposed continuously to 
      rat pups, a process called sensitization. Maternal behavior in juveniles is 
      robust and is similar to adult maternal behavior (Mayer and Rosenblatt [1979] 
      Dev. Psychobiol. 12:407-424; Gray and Chesley [684] J. Comp. Psychol. 98:91-99). 
      In this study, immunocytochemical detection of the protein products of two 
      immediate-early genes, c-fos and fosB, was used as a tool to identify forebrain 
      neuronal populations involved in the maternal behavior of 27-day-old juvenile 
      rats compared with 60-day-old adults. To sensitize them, rats were exposed 
      continuously to foster pups. Once they were maternal, they were isolated from 
      pups overnight, reexposed to pups for 2 hours, and then killed. Nonmaternal 
      control animals also were isolated overnight and were either reexposed to pups 
      for 2 hours or kept isolated from pups before killing. The lateral habenula (LH) 
      was the only area in which both maternal juveniles and maternal adults had more 
      c-Fos-immunoreactive (-Ir) neurons compared with controls. In maternal adults, 
      the number of neurons that expressed c-Fos and FosB immunoreactivity increased in 
      the medial preoptic area (MPO) and the ventral bed nucleus of the stria 
      terminalis (BSTv), whereas the dorsal bed nucleus of the stria terminalis (BSTd) 
      and the medial and cortical nuclei of the amygdala (MEA and COA, respectively) 
      had increases only in the number of neurons that expressed c-Fos 
      immunoreactivity. In contrast, juveniles, whether or not they were maternal, had 
      the same number of c-Fos-IR and FosB-Ir neurons in all these areas. The 
      adult-like increase in the number of c-Fos-Ir neurons found in maternal juveniles 
      suggests that the juvenile LH participates in the neural circuit that supports 
      maternal behavior in an adult-like manner. The lack of c-fos or fosB induction in 
      the MPO, BSTv, BSTd, COA, or MEA of maternal juveniles compared with maternal 
      adults may reflect the immaturity of these brain regions in juvenile rats. 
      Exactly what this immaturity consists of and when the responses of these regions 
      become adult-like remain to be determined.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Kalinichev, M
AU  - Kalinichev M
AD  - Center for Molecular and Behavioral Neuroscience, Aidekman Research Center, 
      Rutgers University, Newark, New Jersey 07102, USA.
FAU - Rosenblatt, J S
AU  - Rosenblatt JS
FAU - Nakabeppu, Y
AU  - Nakabeppu Y
FAU - Morrell, J I
AU  - Morrell JI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Female
MH  - Gene Expression Regulation
MH  - Immunohistochemistry
MH  - Maternal Behavior/*physiology
MH  - Neurons/*physiology
MH  - Ovariectomy
MH  - Prosencephalon/growth & development/*physiology
MH  - Proto-Oncogene Proteins c-fos/analysis/*genetics
MH  - Rats
MH  - Social Behavior
EDAT- 1999/12/01 00:00
MHDA- 1999/12/01 00:01
CRDT- 1999/12/01 00:00
PHST- 1999/12/01 00:00 [pubmed]
PHST- 1999/12/01 00:01 [medline]
PHST- 1999/12/01 00:00 [entrez]
AID - 10.1002/(SICI)1096-9861(20000103)416:1<45::AID-CNE5>3.0.CO;2-K [pii]
AID - 10.1002/(sici)1096-9861(20000103)416:1<45::aid-cne5>3.0.co;2-k [doi]
PST - ppublish
SO  - J Comp Neurol. 2000 Jan 3;416(1):45-78. doi: 
      10.1002/(sici)1096-9861(20000103)416:1<45::aid-cne5>3.0.co;2-k.