PMID- 10579372 OWN - NLM STAT- MEDLINE DCOM- 19991221 LR - 20190905 IS - 0010-440X (Print) IS - 0010-440X (Linking) VI - 40 IP - 6 DP - 1999 Nov-Dec TI - Bipolar II versus unipolar chronic depression: a 312-case study. PG - 418-21 AB - Differences between bipolar II depression and unipolar depression have been reported, such as a lower age at onset and more atypical features in bipolar II depression. The aim of the present study was to compare chronic/nonchronic bipolar II depression with chronic/nonchronic unipolar depression to determine whether the reported differences are present when chronicity is taken into account. Three hundred twelve outpatients in a bipolar II/unipolar major depressive episode were assessed with the Structured Clinical Interview for DSM-IV-Clinician Version (SCID-CV), the Montgomery and Asberg Depression Rating Scale (MADRS), and the Global Assessment of Functioning (GAF) Scale. No significant difference was found between chronic bipolar II and chronic unipolar depression (age at intake and onset, gender, duration of illness, recurrences, psychosis, atypical features, axis I comorbidity, and severity). A significantly lower age at onset and more atypical features were observed when comparing chronic/nonchronic bipolar II with nonchronic unipolar depression. These findings suggest that differences reported between bipolar II and unipolar depression are mainly due to nonchronic unipolar depression. Chronic unipolar depression may be a subtype intermediate between bipolar II depression and nonchronic unipolar depression. FAU - Benazzi, F AU - Benazzi F AD - Department of Psychiatry, Public Hospital Morgagni, Forli, Italy. LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Compr Psychiatry JT - Comprehensive psychiatry JID - 0372612 SB - IM MH - Adult MH - Bipolar Disorder/*diagnosis MH - Case-Control Studies MH - Chronic Disease MH - Depressive Disorder, Major/*diagnosis MH - Female MH - Humans MH - Male MH - Psychiatric Status Rating Scales MH - Severity of Illness Index EDAT- 1999/12/01 00:00 MHDA- 1999/12/01 00:01 CRDT- 1999/12/01 00:00 PHST- 1999/12/01 00:00 [pubmed] PHST- 1999/12/01 00:01 [medline] PHST- 1999/12/01 00:00 [entrez] AID - S0010-440X(99)90084-6 [pii] AID - 10.1016/s0010-440x(99)90084-6 [doi] PST - ppublish SO - Compr Psychiatry. 1999 Nov-Dec;40(6):418-21. doi: 10.1016/s0010-440x(99)90084-6.