PMID- 10580602
OWN - NLM
STAT- MEDLINE
DCOM- 19991229
LR  - 20190921
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 42
IP  - 4
DP  - 1999 Oct
TI  - A placenta-derived suppressor factor with a T-cell bias.
PG  - 205-18
AB  - PROBLEM: Functional and mechanistic aspects of immunosuppression by murine 
      placental supernatants (MPS) were investigated. METHOD OF STUDY: MPS and a low 
      molecular weight fraction of the supernatant (MPSf) were tested for suppressive 
      action on T-cell reactivity in vitro and in vivo, on B-cell responses and on 
      T-cell activation events. RESULTS: MPS and MPSf suppress mitogen-induced 
      proliferation and mixed lymphocyte reactions of human and murine lymphocytes, 
      antigen-induced proliferation of T cells in vitro and in vivo, proliferation of 
      CD8+ lymphocytes, proliferation induced by cross-linking of surface CD3 and the 
      in vivo response of mice to allogeneic stimuli. MPSf affects cell cycling of 
      activated T cells and blocks interleukin (IL)-2 production. MPSf does not affect 
      antibody production or the induction of MHC class II expression on B cells. 
      CONCLUSIONS: MPSf is a potent inhibitor of T-cell responses in vitro and in vivo, 
      with no demonstrable effect on B-cell function.
FAU - Raghupathy, R
AU  - Raghupathy R
AD  - Department of Microbiology, Faculty of Medicine, Kuwait University. 
      raj@hsc.kuniv.edu.kw
FAU - Khan, S F
AU  - Khan SF
FAU - Syamasundar, P V
AU  - Syamasundar PV
FAU - Bansal, P
AU  - Bansal P
FAU - Azizieh, F
AU  - Azizieh F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (CD3 Complex)
RN  - 0 (Interleukin-2)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Suppressor Factors, Immunologic)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
CIN - Am J Reprod Immunol. 1999 Oct;42(4):199-204. PMID: 10580601
MH  - Animals
MH  - B-Lymphocytes/cytology/immunology
MH  - CD3 Complex/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cell Division/immunology
MH  - Female
MH  - Humans
MH  - Interferon-gamma/pharmacology
MH  - Interleukin-2/antagonists & inhibitors/metabolism
MH  - Interleukin-4/pharmacology
MH  - K562 Cells
MH  - Lymphocyte Activation/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/immunology/pharmacology
MH  - Pregnancy
MH  - Pregnancy Proteins/isolation & purification/*physiology
MH  - Receptors, Interleukin-2/antagonists & inhibitors/biosynthesis
MH  - Suppressor Factors, Immunologic/isolation & purification/*physiology
MH  - T-Lymphocytes/*immunology
EDAT- 1999/12/02 00:00
MHDA- 1999/12/02 00:01
CRDT- 1999/12/02 00:00
PHST- 1999/12/02 00:00 [pubmed]
PHST- 1999/12/02 00:01 [medline]
PHST- 1999/12/02 00:00 [entrez]
AID - 10.1111/j.1600-0897.1999.tb00093.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 1999 Oct;42(4):205-18. doi: 
      10.1111/j.1600-0897.1999.tb00093.x.