PMID- 10581088
OWN - NLM
STAT- MEDLINE
DCOM- 19991229
LR  - 20221207
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 5
IP  - 12
DP  - 1999 Dec
TI  - The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an 
      Andean mummy.
PG  - 1428-32
AB  - The worldwide geographic and ethnic clustering of patients with diseases related 
      to human T-cell lymphotropic virus type I (HTLV-I) may be explained by the 
      natural history of HTLV-I infection. The genetic characteristics of indigenous 
      people in the Andes are similar to those of the Japanese, and HTLV-I is generally 
      detected in both groups. To clarify the common origin of HTLV-I in Asia and the 
      Andes, we analyzed HTLV-I provirus DNA from Andean mummies about 1,500 years old. 
      Two of 104 mummy bone marrow specimens yielded a band of human beta-globin gene 
      DNA 110 base pairs in length, and one of these two produced bands of HTLV-I-pX 
      (open reading frame encoding p40x, p27x) and HTLV-I-LTR (long terminal repeat) 
      gene DNA 159 base pairs and 157 base pairs in length, respectively. The 
      nucleotide sequences of ancient HTLV-I-pX and HTLV-I-LTR clones isolated from 
      mummy bone marrow were similar to those in contemporary Andeans and Japanese, 
      although there was microheterogeneity in the sequences of some mummy DNA clones. 
      This result provides evidence that HTLV-I was carried with ancient Mongoloids to 
      the Andes before the Colonial era. Analysis of ancient HTLV-I sequences could be 
      a useful tool for studying the history of human retroviral infection as well as 
      human prehistoric migration.
FAU - Li, H C
AU  - Li HC
AD  - Department of Virology, Faculty of Medicine, Kagoshima University, 8-35-1 
      Sakuragaoka, Kagoshima 890-8520, Japan.
FAU - Fujiyoshi, T
AU  - Fujiyoshi T
FAU - Lou, H
AU  - Lou H
FAU - Yashiki, S
AU  - Yashiki S
FAU - Sonoda, S
AU  - Sonoda S
FAU - Cartier, L
AU  - Cartier L
FAU - Nunez, L
AU  - Nunez L
FAU - Munoz, I
AU  - Munoz I
FAU - Horai, S
AU  - Horai S
FAU - Tajima, K
AU  - Tajima K
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
RN  - 0 (Retroviridae Proteins, Oncogenic)
RN  - 0 (Transcription Factors)
RN  - 0 (Viral Regulatory and Accessory Proteins)
RN  - 0 (pX protein, Human T-lymphotropic virus 1)
RN  - 9004-22-2 (Globins)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Nat Med. 1999 Dec;5(12):1357. PMID: 10581074
CIN - Nat Med. 2000 Mar;6(3):232-3. PMID: 10700195
CIN - Nat Med. 2000 Mar;6(3):232; author reply 233. PMID: 10700196
MH  - Asian People/history
MH  - Base Sequence
MH  - Chile
MH  - Cloning, Molecular
MH  - DNA/genetics/isolation & purification
MH  - DNA Primers/genetics
MH  - DNA, Viral/genetics/*isolation & purification
MH  - Evolution, Molecular
MH  - Genes, pX
MH  - Globins/genetics
MH  - HTLV-I Infections/*history/virology
MH  - History, Ancient
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Molecular Sequence Data
MH  - Mummies/*virology
MH  - Proviruses/genetics/isolation & purification
MH  - Retroviridae Proteins, Oncogenic/genetics
MH  - Sequence Homology, Nucleic Acid
MH  - Terminal Repeat Sequences
MH  - *Transcription Factors
MH  - Viral Regulatory and Accessory Proteins
EDAT- 1999/12/02 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/12/02 09:00
PHST- 1999/12/02 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/12/02 09:00 [entrez]
AID - 10.1038/71006 [doi]
PST - ppublish
SO  - Nat Med. 1999 Dec;5(12):1428-32. doi: 10.1038/71006.