PMID- 10581496
OWN - NLM
STAT- MEDLINE
DCOM- 20000224
LR  - 20190905
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 88
IP  - 6
DP  - 1999 Dec 15
TI  - Heritability of BDNF alleles and their effect on brain morphology in 
      schizophrenia.
PG  - 724-8
AB  - Accumulating evidence suggests that disturbed brain development may play a role 
      in the etiology of schizophrenia, and that the illness is, to a significant 
      degree, heritable. We therefore investigated brain derived neurotrophic factor 
      (BDNF), a neurotrophin expressed in fetal brain, as a candidate disease gene for 
      schizophrenia. We also investigated the effect of BDNF on adult brain morphology. 
      All subjects were diagnosed by DSM-IIIR or DSM-IV criteria with schizophrenia 
      spectrum disorders. Association of a BDNF polymorphism was examined in 48 
      proband-parent trios using the haplotype based haplotype relative risk method of 
      case control. In a related group of 63 subjects, relationships between the 
      presence or absence of allele 1 and the volumes of the major cerebral lobes, the 
      ventricles, and the cerebellum were assessed using logistic regression. No 
      association was found between this polymorphism and schizophrenia. Subjects who 
      had at least one copy of allele 1, however, had larger parietal lobes than those 
      who did not when controlling for overall cortical volume and age at the time of 
      magnetic resonance. We did not find support for BDNF as a disease gene for 
      schizophrenia. Allelic variability of the gene may, however, influence brain 
      morphology in these same subjects. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 
      88:724-728, 1999.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Wassink, T H
AU  - Wassink TH
AD  - Mental Health Clinical Research Center, Department of Psychiatry, University of 
      Iowa College of Medicine, Iowa. thomas-wassink@uiowa.edu
FAU - Nelson, J J
AU  - Nelson JJ
FAU - Crowe, R R
AU  - Crowe RR
FAU - Andreasen, N C
AU  - Andreasen NC
LA  - eng
GR  - MH00735/MH/NIMH NIH HHS/United States
GR  - MH31593/MH/NIMH NIH HHS/United States
GR  - MH43212/MH/NIMH NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - *Alleles
MH  - Brain/metabolism/*pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/physiology
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation/genetics
MH  - Haplotypes/genetics
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Polymorphism, Genetic/genetics
MH  - Schizophrenia/*genetics/*pathology
EDAT- 1999/12/03 09:00
MHDA- 2000/02/26 09:00
CRDT- 1999/12/03 09:00
PHST- 1999/12/03 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 1999/12/03 09:00 [entrez]
AID - 10.1002/(SICI)1096-8628(19991215)88:6<724::AID-AJMG25>3.0.CO;2-7 [pii]
AID - 10.1002/(sici)1096-8628(19991215)88:6<724::aid-ajmg25>3.0.co;2-7 [doi]
PST - ppublish
SO  - Am J Med Genet. 1999 Dec 15;88(6):724-8. doi: 
      10.1002/(sici)1096-8628(19991215)88:6<724::aid-ajmg25>3.0.co;2-7.