PMID- 10583884
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20191103
IS  - 0958-7578 (Print)
IS  - 0958-7578 (Linking)
VI  - 9
IP  - 4
DP  - 1999 Dec
TI  - Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous 
      immunoglobulin preparations.
PG  - 307-10
AB  - Intravenous immunoglobulin (IVIG) has been used to treat many autoimmune 
      disorders including Stiff-Man Syndrome (SMS). SMS is a neurological disorder 
      associated with an immune-mediated deficiency of gamma-aminobutyric acid (GABA) 
      due to autoantibodies against the GABA synthesizing enzyme glutamic acid 
      decarboxylase-65 (GAD65). GAD65 autoantibodies are present among 1-2% of healthy 
      individuals. It can therefore not be excluded that GAD65 autoantibodies may be 
      present in IVIG, which is prepared from multiple blood donors. We report here 
      that GAD65 but not IA-2 autoantibodies were present in commercial IVIG 
      preparations. The presence of autoantibodies may affect the outcome of IVIG 
      treatment and screening commercial preparations of IVIG for GAD65 autoantibodies 
      is therefore recommended before treating patients.
FAU - Hao, W
AU  - Hao W
AD  - Department of Medicine, University of Washington, Seattle, WA 98195, USA.
FAU - Davis, C
AU  - Davis C
FAU - Daniels, T
AU  - Daniels T
FAU - Hampe, C S
AU  - Hampe CS
FAU - Lernmark, A
AU  - Lernmark A
LA  - eng
GR  - R01 DK026190/DK/NIDDK NIH HHS/United States
GR  - DK26190/DK/NIDDK NIH HHS/United States
GR  - DK53004/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Transfus Med
JT  - Transfusion medicine (Oxford, England)
JID - 9301182
RN  - 0 (Autoantibodies)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Isoenzymes)
RN  - 0 (Recombinant Proteins)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 2)
SB  - IM
MH  - Antibody Affinity
MH  - Antibody Specificity
MH  - Autoantibodies/*blood
MH  - Epitopes
MH  - Glutamate Decarboxylase/*immunology
MH  - Humans
MH  - Immunoglobulins, Intravenous/*chemistry/immunology
MH  - Isoenzymes/*immunology
MH  - Recombinant Proteins/immunology
EDAT- 1999/12/03 00:00
MHDA- 1999/12/03 00:01
CRDT- 1999/12/03 00:00
PHST- 1999/12/03 00:00 [pubmed]
PHST- 1999/12/03 00:01 [medline]
PHST- 1999/12/03 00:00 [entrez]
AID - tme214 [pii]
AID - 10.1046/j.1365-3148.1999.00214.x [doi]
PST - ppublish
SO  - Transfus Med. 1999 Dec;9(4):307-10. doi: 10.1046/j.1365-3148.1999.00214.x.