PMID- 10584206
OWN - NLM
STAT- MEDLINE
DCOM- 20000107
LR  - 20181130
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 21
IP  - 4
DP  - 1999 Nov
TI  - Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type 
      hypersensitivity in rats.
PG  - 705-15
AB  - We investigated the effect of an aqueous extract of Schizonepeta tenuifolia 
      (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited 
      systemic allergic reaction induced by compound 48/80 in rats dose-dependently. 
      STAE also inhibited plasma histamine levels induced by compound 48/80. STAE 
      inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In 
      addition, STAE does-dependently inhibited histamine release from rat peritoneal 
      mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had 
      a significant enhancing effect on anti-DNP IgE-induced tumor necrosis 
      factor-alpha (TNF-alpha) production from RPMC. These results indicate that STAE 
      inhibits immediate-type hypersensitivity and suggest that STAE can selectively 
      activate the TNF-alpha production from RPMC.
FAU - Shin, T Y
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Wanju, Chonbuk, South Korea.
FAU - Jeong, H J
AU  - Jeong HJ
FAU - Jun, S M
AU  - Jun SM
FAU - Chae, H J
AU  - Chae HJ
FAU - Kim, H R
AU  - Kim HR
FAU - Baek, S H
AU  - Baek SH
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Dinitrophenols)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Anaphylaxis/drug therapy/*immunology/prevention & control
MH  - Animals
MH  - Dinitrophenols/immunology
MH  - Dose-Response Relationship, Immunologic
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/immunology
MH  - Lamiaceae/chemistry
MH  - Mast Cells/*drug effects/*immunology/metabolism
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - Peritoneal Cavity/cytology
MH  - Plant Extracts/pharmacology
MH  - Plants, Medicinal/*chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/antagonists & inhibitors/immunology
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.3109/08923979909007136 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 1999 Nov;21(4):705-15. doi: 
      10.3109/08923979909007136.