PMID- 10584265
OWN - NLM
STAT- MEDLINE
DCOM- 19991221
LR  - 20090528
IS  - 0210-0010 (Print)
IS  - 0210-0010 (Linking)
VI  - 29
IP  - 6
DP  - 1999 Sep 16-30
TI  - [Neuronal death mechanisms in cerebral ischemia].
PG  - 515-21
AB  - INTRODUCTION: Morphological and biochemical studies have shown an apoptotic 
      component in neurons following either focal or global ischemia in adults, or 
      hypoxia-ischemia during development. DEVELOPMENT: Different factors, including 
      transcription factors, members of the Bcl-2 family, caspases and trophic factors, 
      participate in the cascade of events leading to cell death. Transcription factor 
      c-Jun is induced and expressed in the three models of ischemia as a non-specific 
      response to the ischemic stress. The role played by the different members of the 
      Bcl-2 family is not clear in cerebral ischemia. It is feasible that Bcl-2 
      expression is not sufficient to protect nerve cells from dying in those animals 
      with physiological dotations of this protein. Yet Bcl-xS may have a role in 
      ischemia-induced cell death following global ischemia in the adult or 
      hypoxia-ischemia during development. Recent studies have also shown a similar 
      putative role of caspase 1 and caspase 3 following cerebral ischemia. Finally, 
      the ischemic insult is usually accompanied by modifications in the expression of 
      neurotrophins and receptors. CONCLUSIONS: Brain-derived neurotrophic factor 
      (BDNF) administration preserves nerve cells from dying following focal or global 
      ischemia in adults, and hypoxia-ischemia during development. This positive effect 
      is probably dependent on the cross-signaling between BDNF and its specific 
      receptor TrkB. Cumulative evidence in experimental models indicates BDNF as a 
      putative agent in the treatment of cerebral ischemia in humans.
FAU - Ferrer, I
AU  - Ferrer I
AD  - Unidad de Neuropatologia, Hospital Principes de Espana, Bellvitge, Espana. 
      iferrer@sakma.es
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Mecanismos de muerte neuronal en la isquemia cerebral.
PL  - Spain
TA  - Rev Neurol
JT  - Revista de neurologia
JID - 7706841
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Apoptosis/drug effects/*genetics
MH  - Brain Ischemia/drug therapy/genetics/*pathology
MH  - Brain-Derived Neurotrophic Factor/pharmacology/therapeutic use
MH  - Cell Death/drug effects/*genetics
MH  - Gene Expression/genetics
MH  - Genes, bcl-2/genetics
MH  - Genes, jun/genetics
MH  - Humans
MH  - Neurons/drug effects/*pathology
MH  - Transcription, Genetic/genetics
RF  - 118
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
PST - ppublish
SO  - Rev Neurol. 1999 Sep 16-30;29(6):515-21.