PMID- 10584550
OWN - NLM
STAT- MEDLINE
DCOM- 20000211
LR  - 20080610
IS  - 1661-8157 (Print)
IS  - 1661-8157 (Linking)
VI  - 88
IP  - 44
DP  - 1999 Oct 28
TI  - [Cutaneous paraneoplastic syndrome as an immunologic phenomenon exemplified by 
      paraneoplastic subacute cutaneous lupus erythematosus].
PG  - 1803-10
AB  - Two case reports and a review of the literature on paraneoplastic figurate 
      erythemas with lupus erythematosus (LE)-specific histolopathology illustrate 
      cutaneous paraneoplasia as an immunological phenomenon. Subacute cutaneous lupus 
      erythematosus (SCLE) is characterized by photosensitive, annular or 
      papulosquamous skin lesions with LE-specific histopathology in association with 
      circulating anti-SS-A (Ro) auto-antibodies. The SS-A (Ro) antigen is a complex of 
      cytoplasmic ribonucleoproteins that translocate to the surface of keratinocytes 
      under UV irradiation. Sequestered cytosolic antigen that is expressed on the cell 
      surface is presented to T lymphocytes by professional antigen presenting cells in 
      the context of specific MHC class II molecules. The initiation of the specific 
      immune response, the expansion of antigen-specific T helper cells, and the 
      differentiation of B cells to antibody producing plasma cells depend on the 
      further interaction with antigen. The risk of a self-perpetuating autoimmune 
      response relies on further release of auto-antigen. It is conceivable that in 
      paraneoplastic SCLE tumor antigen with homology to SS-A (Ro) leads to 
      photosensitive autoreactivity. The review of the literature reveals 9 other cases 
      of SCLE associated with internal malignancy. The most common associated tumors 
      were bronchial and mammary carcinoma. The latency between the appearance of skin 
      lesions and the diagnosis of an underlying tumor was between one month and three 
      years (mean: 10 months). In all cases, skin lesions improved with cancer therapy, 
      in three cases they (re)appeared in association with relapse of tumor.
FAU - Trueb, R F
AU  - Trueb RF
AD  - Dermatologische Klinik, Universitatsspital Zurich. ramitru@derm.unizh.ch
FAU - Trueb, R M
AU  - Trueb RM
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Kutane Paraneoplasie als immunologisches Phanomen am Beispiel des 
      paraneoplastischen subakuten kutanen Lupus erythematodes.
PL  - Switzerland
TA  - Praxis (Bern 1994)
JT  - Praxis
JID - 101468093
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (SS-A antibodies)
SB  - IM
MH  - Adenocarcinoma/immunology/pathology
MH  - Antibodies, Antinuclear/blood
MH  - Carcinoma, Small Cell/immunology/pathology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Lung Neoplasms/immunology/pathology
MH  - Lupus Erythematosus, Cutaneous/*immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Paraneoplastic Syndromes/*immunology/pathology
MH  - Skin/immunology/pathology
RF  - 28
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
PST - ppublish
SO  - Praxis (Bern 1994). 1999 Oct 28;88(44):1803-10.