PMID- 10586892
OWN - NLM
STAT- MEDLINE
DCOM- 19991206
LR  - 20190618
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 402
IP  - 6760 Suppl
DP  - 1999 Nov 25
TI  - Signalling through the high-affinity IgE receptor Fc epsilonRI.
PG  - B24-30
AB  - The Fc epsilonRI complex forms a high-affinity cell-surface receptor for the Fc 
      region of antigen-specific immunoglobulin E (IgE) molecules. Fc epsilonRI is 
      multimeric and is a member of a family of related antigen/Fc receptors which have 
      conserved structural features and similar roles in initiating intracellular 
      signalling cascades. In humans, Fc epsilonRI controls the activation of mast 
      cells and basophils, and participates in IgE-mediated antigen presentation. 
      Multivalent antigens bind and crosslink IgE molecules held at the cell surface by 
      Fc epsilonRI. Receptor aggregation induces multiple signalling pathways that 
      control diverse effector responses. These include the secretion of allergic 
      mediators and induction of cytokine gene transcription, resulting in secretion of 
      molecules such as interleukin-4, interleukin-6, tumour-necrosis factor-alpha and 
      granulocyte-macrophage colony-stimulating factor. Fc epsilonRI is therefore 
      central to the induction and maintenance of an allergic response and may confer 
      physiological protection in parasitic infections.
FAU - Turner, H
AU  - Turner H
AD  - Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts 02215, USA.
FAU - Kinet, J P
AU  - Kinet JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antigens)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.6.1.- (GTP Phosphohydrolases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antigens/immunology/metabolism
MH  - Calcium/metabolism
MH  - Disease Models, Animal
MH  - GTP Phosphohydrolases/metabolism
MH  - Humans
MH  - Hypersensitivity/*immunology/metabolism
MH  - Immunoglobulin E/metabolism
MH  - MAP Kinase Signaling System
MH  - Molecular Sequence Data
MH  - Receptors, IgE/*metabolism
MH  - *Signal Transduction
RF  - 66
EDAT- 1999/12/10 00:00
MHDA- 1999/12/10 00:01
CRDT- 1999/12/10 00:00
PHST- 1999/12/10 00:00 [pubmed]
PHST- 1999/12/10 00:01 [medline]
PHST- 1999/12/10 00:00 [entrez]
AID - 10.1038/35037021 [doi]
PST - ppublish
SO  - Nature. 1999 Nov 25;402(6760 Suppl):B24-30. doi: 10.1038/35037021.