PMID- 10588911
OWN - NLM
STAT- MEDLINE
DCOM- 20000301
LR  - 20091230
IS  - 0882-4010 (Print)
IS  - 0882-4010 (Linking)
VI  - 27
IP  - 6
DP  - 1999 Dec
TI  - Either a CD4(+)or CD8(+)T cell function is sufficient for clearance of infectious 
      virus from trigeminal ganglia and establishment of herpes simplex virus type 1 
      latency in mice.
PG  - 387-94
AB  - Following ocular infection of normal mice, herpes simplex virus type 1 (HSV-1) 
      establishes a latent infection in the trigeminal ganglia (TG) with the complete 
      absence of detectable infectious virus. In this study, the role of CD4(+)and 
      CD8(+)T cell dependent immune responses is examined in relation to clearing 
      infectious virus from the TG following HSV-1 ocular challenge. Nude mice, which 
      lack T cells, and MHC(o/o)mice, which lack both MHC class I and MHC class II, 
      were challenged ocularly with wild-type HSV-1. Over 70% of the TG from mice 
      surviving the infection contained infectious virus, indicative of a chronic 
      infection in these TG, rather than a latent infection. No infectious virus was 
      detected in TGs from infected C57BL/6 parental mice. Ocular challenge of 
      CD4(o/o)A(beta(o/o, CD8(o/o)or beta(2)m(o/o)mice resulted in latent rather than 
      chronic infection. Similarly, when C57BL/6 mice were depleted for CD4(+)or 
      CD8(+)T cells from 4 days before ocular challenge to 26 days after ocular 
      challenge, no free virus was detected in TGs of challenged mice. In contrast, 
      when mice were depleted of both their CD4(+)and CD8(+)T cells, over 90% of TGs 
      were positive for free virus, suggesting that the lack of virus clearance was due 
      to the combined lack of both CD4(+)T cells and CD8(+)T cells (i.e. in the 
      presence of either CD4(+)T cells or CD8(+)T cells alone all of the infectious 
      virus was cleared and latency was established).))
CI  - Copyright 1999 Academic Press.
FAU - Ghiasi, H
AU  - Ghiasi H
AD  - Ophthalmology Research, Cedars-Sinai Burns and Allen Research Institute, CSMC - 
      Davis Bldg, Rm 5072, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
FAU - Perng, G
AU  - Perng G
FAU - Nesburn, A B
AU  - Nesburn AB
FAU - Wechsler, S L
AU  - Wechsler SL
LA  - eng
GR  - EY09224/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Chronic Disease
MH  - Herpes Simplex/*immunology/virology
MH  - Herpesvirus 1, Human/*immunology/pathogenicity
MH  - Keratitis, Herpetic/immunology/virology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Nude
MH  - Trigeminal Ganglion/immunology/*virology
MH  - *Virus Latency
EDAT- 1999/12/10 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/12/10 09:00
PHST- 1999/12/10 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/12/10 09:00 [entrez]
AID - S0882401099903145 [pii]
AID - 10.1006/mpat.1999.0314 [doi]
PST - ppublish
SO  - Microb Pathog. 1999 Dec;27(6):387-94. doi: 10.1006/mpat.1999.0314.