PMID- 10590404
OWN - NLM
STAT- MEDLINE
DCOM- 20000120
LR  - 20190915
IS  - 0148-639X (Print)
IS  - 0148-639X (Linking)
VI  - 23
IP  - 1
DP  - 2000 Jan
TI  - Influence of diabetes mellitus on chronic inflammatory demyelinating 
      polyneuropathy.
PG  - 37-43
AB  - Patients with diabetes occasionally develop clinical and electrodiagnostic 
      features suggestive of chronic inflammatory demyelinating polyneuropathy (CIDP). 
      To clarify the role of diabetes in patients with a CIDP-like syndrome, we 
      compared the clinical, pathological, and electrodiagnostic features of 14 
      patients (10 men, 4 women) with diabetes and CIDP (DM-CIDP) to 60 patients with 
      idiopathic CIDP (I-CIDP). The average duration of diabetes was 9 years. The 
      patients with DM-CIDP were older and more often complained of imbalance compared 
      to the idiopathic group, but the frequency of other symptoms and neurologic 
      findings were similar. The mean amplitude of the ulnar compound muscle action 
      potential in the DM-CIDP group was comparatively reduced, the sural sensory nerve 
      action potential was more often absent, and axonal loss was more commonly 
      observed on nerve biopsy. The response rate to treatment was similar, but the 
      magnitude of functional recovery was greater in patients with I-CIDP. Thus, our 
      patients with diabetes and CIDP had clinical features similar to those with 
      idiopathic CIDP, but their nerve conduction studies and nerve biopsies showed 
      more severe axonal loss and the degree of improvement following treatment was 
      less favorable. These differences most likely reflect the additive effects of 
      superimposed diabetic axonal polyneuropathy in patients who develop CIDP.
CI  - Copyright 2000 John Wiley & Sons, Inc.
FAU - Gorson, K C
AU  - Gorson KC
AD  - Division of Neurology, St. Elizabeth's Medical Center, 736 Cambridge Street, 
      Boston, Massachusetts 02135, USA. KGorson@aol.com
FAU - Ropper, A H
AU  - Ropper AH
FAU - Adelman, L S
AU  - Adelman LS
FAU - Weinberg, D H
AU  - Weinberg DH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Aged
MH  - Axons/pathology
MH  - Demyelinating Diseases/etiology/*pathology/therapy
MH  - Diabetes Mellitus, Type 2/complications/*pathology/therapy
MH  - Diabetic Neuropathies/*pathology/therapy
MH  - Disability Evaluation
MH  - Electrophysiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neural Conduction/physiology
MH  - Neurons, Afferent/pathology
MH  - Treatment Outcome
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - 10.1002/(SICI)1097-4598(200001)23:1<37::AID-MUS5>3.0.CO;2-9 [pii]
AID - 10.1002/(sici)1097-4598(200001)23:1<37::aid-mus5>3.0.co;2-9 [doi]
PST - ppublish
SO  - Muscle Nerve. 2000 Jan;23(1):37-43. doi: 
      10.1002/(sici)1097-4598(200001)23:1<37::aid-mus5>3.0.co;2-9.