PMID- 10591870
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 147
IP  - 1
DP  - 1999 Nov
TI  - A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical 
      responses to subsequent MDMA administration.
PG  - 66-72
AB  - RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) produces a long-term 
      depletion of serotonin (5-HT) in the rat brain; this depletion may have some 
      functional consequences. OBJECTIVE: The aim of the present study was to evaluate 
      the acute effects of MDMA on the extracellular concentrations of dopamine and 
      5-HT, body temperature and the 5-HT behavioral syndrome in rats 7 days following 
      a neurotoxic regimen of MDMA. METHODS: One week after the rats were treated with 
      a neurotoxic regimen of MDMA (10 mg/kg, i.p., every 2 h for a total of four 
      injections), the rats were injected with a subsequent injection of MDMA. In vivo 
      microdialysis combined with HPLC was utilized to measure the extracellular 
      concentration of 5-HT and dopamine in the striatum. The increase in body 
      temperature was determined by rectal temperature measurements, and the 5-HT 
      behavioral syndrome was scored using a rating scale following the administration 
      of MDMA. RESULTS: The neurotoxic regimen produced a 45% reduction in brain 5-HT 
      concentrations. The magnitude of the MDMA-induced increase in the extracellular 
      concentration of 5-HT, but not dopamine, in the striatum produced by an acute 
      injection of MDMA (7.5 mg/kg, i.p.) was reduced in rats treated previously with 
      the neurotoxic regimen of MDMA when compared with that in control animals. In 
      addition, the magnitude of the 5-HT behavioral syndrome, as well as the 
      hyperthermic response, produced by MDMA was markedly diminished in rats that had 
      previously received the neurotoxic regimen of MDMA. CONCLUSIONS: It is concluded 
      that the long-term depletion of brain 5-HT produced by MDMA is accompanied by 
      impairments in 5-HT function, as evidenced by the deficits in the neurochemical, 
      thermal and behavioral responses to subsequent MDMA administration.
FAU - Shankaran, M
AU  - Shankaran M
AD  - College of Pharmacy, University of Cincinnati, OH 45267-0004, USA.
FAU - Gudelsky, G A
AU  - Gudelsky GA
LA  - eng
GR  - DA07427/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 0 (Neurotoxins)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Body Temperature/*drug effects
MH  - Brain Chemistry/*drug effects
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Extracellular Space/drug effects/metabolism
MH  - Hallucinogens/administration & dosage/*toxicity
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Microdialysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*toxicity
MH  - Neurotoxicity Syndromes/*psychology
MH  - Neurotoxins/administration & dosage/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Serotonin Syndrome/psychology
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - 91470066.213 [pii]
AID - 10.1007/s002130051143 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1999 Nov;147(1):66-72. doi: 10.1007/s002130051143.