PMID- 10592847
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20061115
IS  - 0192-415X (Print)
IS  - 0192-415X (Linking)
VI  - 27
IP  - 3-4
DP  - 1999
TI  - Shini-san inhibits mast cell-dependent immediate-type allergic reactions.
PG  - 377-86
AB  - Shini-San has been used for treatment of allergic disease in Korea. However, its 
      effect in experimental models remains unknown. The mast cell plays a pivotal role 
      in initiating allergic response by secreting intracytoplasmic granular mediators 
      such as histamine. The present report describes an inhibitory effect of Shini-San 
      on mast cell-mediated immediate-type allergic reactions. Topical application of 
      compound 48/80 can induce an ear swelling response in normal (WBB6F1(-)+/+) mice 
      but not in congenic mast cell-deficient WBB6F1-W/WV mice. Shini-San inhibited 
      concentration-dependent mast cell-dependent ear swelling response induced by 
      compound 48/80 in normal mice. Shini-San inhibited concentration-dependent 
      passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) immunoglobulin 
      E (IgE) in rats by topical application. Shini-San also inhibited in 
      concentration-dependent fashion the histamine release from the rat peritoneal 
      mast cells by compound 48/80 or anti-DNP IgE. Moreover, Shini-San had a 
      significant inhibitory effect on compound 48/80-induced systemic anaphylactic 
      reaction. These results indicate that Shini-San inhibits immediate type allergic 
      reactions by inhibition of mast cell degranulation in vivo and in vitro.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea.
FAU - Lee, Y H
AU  - Lee YH
FAU - Chae, H J
AU  - Chae HJ
FAU - Kim, H R
AU  - Kim HR
FAU - Baek, S H
AU  - Baek SH
FAU - Lim, K S
AU  - Lim KS
FAU - Hwang, C Y
AU  - Hwang CY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Plant Extracts)
RN  - 0 (shini-san)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Edema/chemically induced/prevention & control
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/*drug therapy/immunology/metabolism
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Pharmaceutical Preparations
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine/antagonists & inhibitors/pharmacology
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - S0192415X99000434 [pii]
AID - 10.1142/S0192415X99000434 [doi]
PST - ppublish
SO  - Am J Chin Med. 1999;27(3-4):377-86. doi: 10.1142/S0192415X99000434.