PMID- 10593370
OWN - NLM
STAT- MEDLINE
DCOM- 19991228
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 72
IP  - 6
DP  - 1999 Dec
TI  - 11beta-hydroxyandrostenedione and delta5-androstenediol as markers of adrenal 
      androgen production in patients with 21-hydroxylase-deficient nonclassic adrenal 
      hyperplasia.
PG  - 996-1000
AB  - OBJECTIVE: To determine the sensitivity of 11beta-hydroxyandrostenedione 
      (11-OHA4) and delta5-androstenediol (ADIOL) as markers of excessive adrenal 
      androgen production. DESIGN: Prospective study. SETTING: Academic medical 
      centers. PATIENT(S): Thirteen women with untreated 21-hydroxylase-deficient 
      nonclassic adrenal hyperplasia (NCAH) and 18 healthy, eumenorrheic, nonhirsute 
      controls matched for age and body mass index. INTERVENTION(S): All subjects were 
      studied before and after acute adrenal stimulation with 0.25 mg of IV 
      ACTH-(1-24). MAIN OUTCOME MEASURE(S): Basal levels of total testosterone, sex 
      hormone-binding globulin, DHEAS, and free testosterone were measured. Levels of 
      androstenedione (A4), DHEA, 11-OHA4, and ADIOL were determined before (Steroid0) 
      and 60 minutes after (Steroid60) acute ACTH-(1-24) stimulation. RESULT(S): 
      Patients with NCAH had higher median basal levels of DHEAS and total and free 
      testosterone than controls. Patients with NCAH had higher median A4(0), A460, 
      DHEA(0), DHEA60, 11-OHA4(0), ADIOL0, and ADIOL60 levels but similar 11-OHA4(60) 
      levels compared with controls. Among patients with NCAH, 30%, 54%, 15%, and 85% 
      had 11-OHA4(0), ADIOL0, 11-OHA4(60), and ADIOL(60) levels, respectively, above 
      the 95th percentile of controls. CONCLUSION(S): Overall, serum levels of 11-OHA4 
      did not appear to be a very sensitive marker of excessive adrenal androgen 
      production, at least in patients with NCAH. Although ACTH-stimulated ADIOL levels 
      were elevated in 85% of the patients studied, they did not appear to have any 
      advantage over the measurement of A4 or DHEA levels.
FAU - Huerta, R
AU  - Huerta R
AD  - Instituto de Investigaciones Medicas, Universidad de Guanajuato, Leon, Mexico.
FAU - Dewailly, D
AU  - Dewailly D
FAU - Decanter, C
AU  - Decanter C
FAU - Knochenhauer, E S
AU  - Knochenhauer ES
FAU - Boots, L R
AU  - Boots LR
FAU - Azziz, R
AU  - Azziz R
LA  - eng
GR  - R01-HD29364/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - 0 (Androgens)
RN  - 0 (Biomarkers)
RN  - 409J2J96VR (Androstenedione)
RN  - 564-32-9 (11-hydroxyandrostenedione)
SB  - IM
MH  - *Adrenal Hyperplasia, Congenital/*metabolism
MH  - Adult
MH  - Androgens/*biosynthesis
MH  - Androstenedione/*analogs & derivatives/blood
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 1999/12/11 00:00
MHDA- 1999/12/11 00:01
CRDT- 1999/12/11 00:00
PHST- 1999/12/11 00:00 [pubmed]
PHST- 1999/12/11 00:01 [medline]
PHST- 1999/12/11 00:00 [entrez]
AID - S0015-0282(99)00402-1 [pii]
AID - 10.1016/s0015-0282(99)00402-1 [doi]
PST - ppublish
SO  - Fertil Steril. 1999 Dec;72(6):996-1000. doi: 10.1016/s0015-0282(99)00402-1.