PMID- 10596682
OWN - NLM
STAT- MEDLINE
DCOM- 20000107
LR  - 20220331
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 14
IP  - 5
DP  - 1999 Nov
TI  - Bronchodilator responsiveness and serum total IgE levels in families of probands 
      with severe early-onset COPD.
PG  - 1009-14
AB  - Bronchodilator responsiveness has been associated with a subsequent accelerated 
      decline in forced expiratory volume in one second (FEV1). Therefore, 
      bronchodilator responsiveness and total serum immunoglobulin E(IgE) levels were 
      assessed in 184 adult first-degree relatives of probands with severe early-onset 
      chronic obstructive pulmonary disease (COPD) and a control group. Greater 
      bronchodilator responsiveness was found among current smokers or exsmokers who 
      were first-degree relatives of early-onset COPD probands than in currently or 
      exsmoking controls, expressed as increase in FEV1 as a percentage of baseline 
      (5.8+/-8.1 versus 2.9+/-5.1%, p<0.01), absolute increase in FEV1 from baseline 
      (120+/-130 versus 60+/-110 mL, p<0.05), and increase in FEV1 as a percentage of 
      the predicted value (3.6:4.1 versus 2.2+/-3.9%, p<0.05). However, elevated total 
      serum IgE levels were not found in first-degree relatives of early-onset COPD 
      probands compared with control subjects. The increased bronchodilator 
      responsiveness among currently smoking/exsmoking first-degree relatives of 
      early-onset COPD probands suggests that these individuals may have enhanced 
      susceptibility to the detrimental effects of cigarette smoking.
FAU - Celedon, J C
AU  - Celedon JC
AD  - Channing Laboratory, Dept of Medicine, Brigham and Women's Hospital, Boston, MA, 
      USA.
FAU - Speizer, F E
AU  - Speizer FE
FAU - Drazen, J M
AU  - Drazen JM
FAU - Weiss, S T
AU  - Weiss ST
FAU - Campbell, E J
AU  - Campbell EJ
FAU - Carey, V J
AU  - Carey VJ
FAU - Reilly, J J
AU  - Reilly JJ
FAU - Ginns, L
AU  - Ginns L
FAU - Silverman, E K
AU  - Silverman EK
LA  - eng
GR  - HL07427/HL/NHLBI NIH HHS/United States
GR  - HL46440/HL/NHLBI NIH HHS/United States
GR  - MO1 RR02635/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Bronchial Provocation Tests
MH  - Bronchoconstriction/*physiology
MH  - Case-Control Studies
MH  - Family
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Lung Diseases, Obstructive/etiology/*genetics
MH  - Middle Aged
MH  - Smoking/physiopathology
MH  - Spirometry
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1183/09031936.99.14510099 [doi]
PST - ppublish
SO  - Eur Respir J. 1999 Nov;14(5):1009-14. doi: 10.1183/09031936.99.14510099.