PMID- 10596713
OWN - NLM
STAT- MEDLINE
DCOM- 20000107
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 14
IP  - 5
DP  - 1999 Nov
TI  - Alveolar macrophage immaturity in infants and young children.
PG  - 1198-205
AB  - Very little is known about alveolar macrophage (AM) immunological function in 
      early childhood. Using nonbronchoscopic bronchoalveolar lavage (BAL), this study 
      sought to compare the proportion, number, and function of AM between very young 
      and older children. BAL fluid (BALF) leukocyte parameters were determined in 63 
      children, and data divided into 3 age groups: group 1 (<2 yrs), group 2 (> or 
      =2-< or =5 yrs) and group 3 (> or =6-< or =17 years). In a further subgroup of 
      children, AM function and immune receptor expression were assessed, and data 
      categorized into two age groups: <2 yrs and > or =2 yrs of age. Compared to 
      groups 2 and 3, the AM percentage in the BAL in group 1 was significantly 
      increased (median: 98% versus 92% and 91%), as was the albumin-adjusted AM 
      concentration. AM from children <2 yrs expressed less human leukocyte antigen 
      (HLA)-DR (versus > or =2 yrs of age), were less effective in reducing nitro blue 
      tetrazolium, and released less interleukin (IL)-1 and tumour necrosis factor on 
      lipopolysaccharide stimulation. There was no difference in release of IL-6, 
      expression of intercellular adhesion molecule-1 (CD54), and AM stimulation of 
      allogeneic T-cells, between children <2 yrs and > or =2 yrs of age. It was 
      concluded that the capacity of alveolar macrophage to stimulate T-cells is not 
      enhanced in early childhood, and that immaturity of alveolar macrophage function 
      may contribute to an increased susceptibility to respiratory infections in this 
      age group.
FAU - Grigg, J
AU  - Grigg J
AD  - Dept of Thoracic Medicine, Royal Children's Hospital Melbourne, Victoria, 
      Australia.
FAU - Riedler, J
AU  - Riedler J
FAU - Robertson, C F
AU  - Robertson CF
FAU - Boyle, W
AU  - Boyle W
FAU - Uren, S
AU  - Uren S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Aging/immunology
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Child
MH  - Child, Preschool
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Interleukin-1/metabolism
MH  - Interleukin-6/metabolism
MH  - Macrophages, Alveolar/*immunology
MH  - Respiratory Tract Infections/*immunology
MH  - T-Lymphocytes/immunology
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1183/09031936.99.14511989 [doi]
PST - ppublish
SO  - Eur Respir J. 1999 Nov;14(5):1198-205. doi: 10.1183/09031936.99.14511989.