PMID- 10596724
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20191024
IS  - 0743-5800 (Print)
IS  - 0743-5800 (Linking)
VI  - 25
IP  - 3-4
DP  - 1999 Aug-Nov
TI  - NT-3: an additional neurotrophin expressed in the adult rat pituitary.
PG  - 295-305
AB  - Neurotrophins mediate a variety of essential biological functions in the nervous 
      system. Evidence has emerged that this class of proteins is also implicated 
      outside the nervous system, in the pituitary. The study described here aims to 
      understand the expression of neurotrophins in the pituitary. We previously 
      reported the presence of nerve growth factor (NGF) and brain derived neurotrophic 
      factor (BDNF) proteins in association with the thyroid stimulating hormone (TSH) 
      and the corresponding mRNAs in the anterior lobe (AL) of the pituitary of adult 
      rats (1). The present study reveals the expression of NGF and BDNF mRNAs in the 
      intermediate plus posterior lobe (IL+PL) as well, and the previously unidentified 
      NT-3 mRNA in the AL and IL+PL. In addition, NGF, BDNF and NT-3 mRNAs are 
      expressed by dissociated AL cells and IL+PL cells, demonstrating their in situ 
      synthesis in endocrine cells of the gland. These findings are new inference for 
      the investigation of the regulation of the synthesis and the secretion of 
      neurotrophins by pituitary cells, with the goal to gain more insight into their 
      function in the hypophysis.
FAU - Amoureux, M C
AU  - Amoureux MC
AD  - Department of Biology, University of California San Diego, La Jolla 92093, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Endocr Res
JT  - Endocrine research
JID - 8408548
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - *Gene Expression
MH  - Male
MH  - Nerve Growth Factor/genetics
MH  - Neurotrophin 3/*genetics
MH  - Pituitary Gland/chemistry/*metabolism
MH  - Pituitary Gland, Anterior/chemistry
MH  - Pituitary Gland, Posterior/chemistry
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1080/07435809909066149 [doi]
PST - ppublish
SO  - Endocr Res. 1999 Aug-Nov;25(3-4):295-305. doi: 10.1080/07435809909066149.