PMID- 10600012
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20190905
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 60
IP  - 11
DP  - 1999 Nov
TI  - The influence of age at onset and gender on the HLA-DQA1, DQB1 association in 
      Chinese children with insulin dependent diabetes mellitus.
PG  - 1131-7
AB  - Certain alleles of human leukocyte antigen (HLA)-DR and -DQ genes have been 
      strongly associated with susceptibility and resistance to insulin- dependent 
      diabetes mellitus (IDDM). To further clarify the association of HLA DQ alleles 
      with IDDM and the influence of age at onset and gender on the association with 
      IDDM, we investigated the association of HLA-DQA1, -DQB1 in 54 childhood onset 
      Chinese (21 male) IDDM patients and 65 normal controls by using polymerase chain 
      reaction-sequence specific primer (PCR-SSP). The mean age plus or minus SD at 
      onset of IDDM patients was 8.37+/-3.54 year old. Our results revealed that the 
      frequencies of DQA1 *0301, *0302, DQB1 *0201, and *0302 in IDDM patients were 
      significantly higher than that in the control group (p < 0.025, < 0.005, < 0.001, 
      and < 0.001, respectively). The frequency of DQA1 *0301, *0302, DQB1 *0201, and 
      *0302 were susceptible alleles to IDDM with relative risks of 2.0, 3.5, 5.0 and 
      4.3, respectively. The protective alleles to IDDM were DQA1 *0101, *0103, DQB1 
      *0301, *0503, and *0602. We divided IDDM patients into three groups according to 
      age at onset (1-5, 6-10, and 11-15 years old). The frequency of DQA1 *0302 
      decreased as age increased, and the frequency of DQA1 *0501 increased as age 
      increased. Our results also showed that male IDDM patients had higher frequencies 
      of DQA *0501, DQB1 *0201 than female IDDM patients (p < 0.025 and < 0.025, 
      respectively), while female IDDM patients had higher frequencies of DQB1 *0502 
      than male IDDM patients (p < 0.05). In our study significant susceptibility 
      haplotypes to IDDM were DQA1 *0301-DQB1 *0302, DQA1 *0501-DQB1 *0201, DQA1 
      *0301-DQB1 *0201, and DQA *0302-DQB1 *0201.
FAU - Chen, B H
AU  - Chen BH
AD  - Department of Clinical Laboratory, Kaohsiung Medical College Hospital, Taiwan, 
      Republic of China.
FAU - Chiang, C H
AU  - Chiang CH
FAU - Lin, S R
AU  - Lin SR
FAU - Chao, M G
AU  - Chao MG
FAU - Tsai, S T
AU  - Tsai ST
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Male
MH  - Sex Characteristics
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0198-8859(99)00106-8 [pii]
AID - 10.1016/s0198-8859(99)00106-8 [doi]
PST - ppublish
SO  - Hum Immunol. 1999 Nov;60(11):1131-7. doi: 10.1016/s0198-8859(99)00106-8.