PMID- 10601082
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190513
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 14
IP  - 12
DP  - 1999 Dec
TI  - Studies on the HLA-DRB1 genotypes in Japanese women with severe pre-eclampsia 
      positive and negative for anticardiolipin antibody using a polymerase chain 
      reaction-restriction fragment length polymorphism method.
PG  - 2980-6
AB  - The human leukocyte antigen (HLA)-DR genotype was determined in 54 Japanese women 
      with severe pre-eclampsia in order to elucidate the relationship between HLA-DR 
      antigen systems and pre-eclampsia. The patients were divided into two groups 
      according to positivity for the anticardiolipin antibody (ACA), i.e. one patient 
      group negative for ACA (n = 41) and the other patient group positive for ACA (n = 
      13). The frequency of each HLA-DRB1 allele in both groups was compared with that 
      in 81 normally fertile Japanese women who had not experienced pre-eclampsia. The 
      genotypes of HLA-DR antigens were determined using a polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) method. The 
      frequency of DRB1*04 and DRB1*0403 in the patient group positive for the ACA was 
      significantly higher compared with that in the group of normal fertile women (P< 
      0.05). The frequency of each HLA-DRB1 allele was not significantly different 
      between patient group with pre-eclampsia negative for ACA and group of normal 
      fertile women. These results suggest a difference in the immunogenetic background 
      between the patient groups with severe pre-eclampsia positive and negative for 
      the ACA.
FAU - Takakuwa, K
AU  - Takakuwa K
AD  - Department of Obstetrics and Gynecology, Niigata University School of Medicine, 
      1-757, Asahimachi-dori, Niigata, 951-8510, Japan.
FAU - Honda, K
AU  - Honda K
FAU - Ishii, K
AU  - Ishii K
FAU - Hataya, I
AU  - Hataya I
FAU - Yasuda, M
AU  - Yasuda M
FAU - Tanaka, K
AU  - Tanaka K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
CIN - Hum Reprod. 2000 Nov;15(11):2447. PMID: 11056152
MH  - Adult
MH  - Alleles
MH  - Antibodies, Anticardiolipin/*analysis
MH  - Chromosome Mapping
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Japan
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Pre-Eclampsia/*genetics/*immunology
MH  - Pregnancy
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1093/humrep/14.12.2980 [doi]
PST - ppublish
SO  - Hum Reprod. 1999 Dec;14(12):2980-6. doi: 10.1093/humrep/14.12.2980.