PMID- 10602290
OWN - NLM
STAT- MEDLINE
DCOM- 20000118
LR  - 20051116
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 47
IP  - 5
DP  - 1999 Dec 1
TI  - Gap junctions in intestinal smooth muscle and interstitial cells of Cajal.
PG  - 309-20
AB  - This manuscript reviews gap junctions' roles in control of intestinal motility. 
      Gap junctions (GJs) of small intestine (SmIn) are found between circular muscle 
      (CM) cells, between interstitial cells of Cajal (ICC) of deep muscular plexus 
      (DMP) and between them and adjacent outer circular muscle (OCM). GJs between 
      longitudinal muscle (LM) cells or between cells of inner circular muscle (ICM) 
      have not been reported. Occasional GJs have been reported between ICC of the 
      myenteric plexus (MyP) and rarely between these ICC and adjacent LM or CM cells, 
      or between ICC within CM and smooth muscle cells. In the colon (Co) of several 
      species a special network of ICC lines the inner border of CM, the submuscular 
      plexus (SP). GJs are found between ICCs and between them and CM cells. The ICC of 
      MyP of Co are associated with LM and CM; occasional GJs exist between ICC and 
      each muscle layer. Small GJs are missed by electron microscopy or light 
      microscopic Immunocytochemistry. Therefore, GJ coupling may exist without 
      demonstrated GJs. The consequences for the pacemaking functions of ICC networks 
      of varied densities of GJ between ICC and between ICC of MyP or DMP or of SP and 
      CM are considered. Connexins (Cxs) that compose intestinal GJs may affect 
      coupling, but are incompletely known. Understanding of the role of GJs in 
      coordinating intestinal motility requires knowing: (1) what passes through gap 
      junctions to couple ICC to smooth muscle cells; (2) what Cx with what 
      conductances and what modulatory controls connect ICC and smooth muscle cells; 
      (3) whether smooth muscles can generate slow waves independent of ICC networks; 
      and (4) what happens to motility, slow waves, and IJPs when GJs are selectively 
      uncoupled.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Daniel, E E
AU  - Daniel EE
AD  - Department of Medicine, Faculty of Health Sciences, McMaster University, 
      Hamilton, Ontario, L8N 3Z5, Canada. daniele@fhs.csu.mcmaster.ca
FAU - Wang, Y F
AU  - Wang YF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Connexins)
SB  - IM
MH  - Animals
MH  - Connexins/analysis
MH  - Gap Junctions/chemistry/physiology/*ultrastructure
MH  - Immunohistochemistry
MH  - Intestines/chemistry/*ultrastructure
MH  - Microscopy, Electron
MH  - Muscle, Smooth/chemistry/*ultrastructure
MH  - Myenteric Plexus/chemistry/ultrastructure
RF  - 90
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1002/(SICI)1097-0029(19991201)47:5<309::AID-JEMT2>3.0.CO;2-K [pii]
AID - 10.1002/(SICI)1097-0029(19991201)47:5<309::AID-JEMT2>3.0.CO;2-K [doi]
PST - ppublish
SO  - Microsc Res Tech. 1999 Dec 1;47(5):309-20. doi: 
      10.1002/(SICI)1097-0029(19991201)47:5<309::AID-JEMT2>3.0.CO;2-K.