PMID- 10603273
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20080828
IS  - 0016-6480 (Print)
IS  - 0016-6480 (Linking)
VI  - 116
IP  - 3
DP  - 1999 Dec
TI  - Actions of two forms of gonadotropin releasing hormone and a GnRH antagonist on 
      spawning behavior of the goldfish Carassius auratus.
PG  - 347-55
AB  - The central effects of two native forms of gonadotropin-releasing hormone (GnRH), 
      salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), and a GnRH antagonist, 
       inverted question markAc-delta 3-Pro(1), 4FD-Phe(2), D-Trp(3, 6)mGnRH (analog E), on the spawning 
      behavior of sexually recrudescent female goldfish were investigated. The effects 
      of analog E were also observed in mature males. Female spawning behavior was 
      induced by intramuscular injection of females with prostaglandin F(2alpha) and 
      placing them in the presence of mature males. Behavioral responses were 
      quantified by recording the numbers of spawning acts performed by each pair of 
      fish for 2 h following brain intracerebroventricular (icv) injection of different 
      dosages of peptide or saline as control. For males, the time spent courting the 
      female was recorded. Each pair of fish was pretested to determine their level of 
      spawning behavior, for comparison to spawning behavior following icv treatment. 
      Icv injection of analog E caused a significant decrease in the number of spawning 
      acts performed by females, suggesting a role of endogenous GnRH in modulating 
      female spawning behavior. icv injection of 0.5 ng/g of sGnRH or cGnRH-II 
      significantly stimulated female spawning behavior, whereas doses of 1 ng/g and 
      higher resulted in an almost complete inhibition of spawning, reflecting a 
      down-regulation as a result of the excessive dosages. Analog E suppressed the 
      actions of exogenous sGnRH and cGnRH-II on spawning behavior, as both the sGnRH- 
      and cGnRH-II-induced increases in the number of spawning acts were inhibited by 
      concomitant treatment with analog E. Analog E-injected males showed no alteration 
      in courtship behavior. These results indicate that GnRH peptides play a major 
      role in the control of female reproductive behavior in goldfish, but have little 
      or no role in the control of male behavior.
CI  - Copyright 1999 Academic Press.
FAU - Volkoff, H
AU  - Volkoff H
AD  - Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 
      2E9, Canada.
FAU - Peter, R E
AU  - Peter RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 78708-43-7 (LHRH, Ac-dehydro-Pro(1)-4-F-Phe(2)-Trp(3,6)-)
RN  - 91097-16-4 (LHRH, His(5)-Trp(7)-Tyr(8)-)
SB  - IM
MH  - Animals
MH  - Female
MH  - Goldfish/*physiology
MH  - Gonadotropin-Releasing Hormone/administration & dosage/analogs & 
      derivatives/*antagonists & inhibitors/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Sex Characteristics
MH  - Sexual Behavior, Animal/*drug effects
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0016-6480(99)97377-X [pii]
AID - 10.1006/gcen.1999.7377 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 1999 Dec;116(3):347-55. doi: 10.1006/gcen.1999.7377.