PMID- 10603309
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20161124
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 266
IP  - 3
DP  - 1999 Dec 29
TI  - Angiogenesis: how a tumor adapts to hypoxia.
PG  - 718-22
AB  - The growth of new blood vessels from the preexisting vascular tree, also known as 
      angiogenesis, occurs in situations such as wound and fracture healing, arthritis, 
      cardiovascular and cerebral ischemia, and nearly every type of cancer known. 
      Vascular endothelial growth factor (VEGF) has been shown to play a crucial role 
      in these events. Hypoxia-dependent VEGF induction is mediated by 
      hypoxia-inducible factor-1 (HIF-1). HIF-1 is a heterodimeric transcription factor 
      tightly regulated by oxygen concentration. In this short review, we summarize 
      recent data concerning the control of HIF-1 activity and notably the regulation 
      of HIF-1alpha subunit by phosphorylation and the ubiquitin proteasomal 
      degradation system. A complete knowledge of this mechanism could, by the design 
      of new antiangiogenic strategies, have a strong impact in clinical oncology.
CI  - Copyright 1999 Academic Press.
FAU - Richard, D E
AU  - Richard DE
AD  - Institute of Signaling, UMR CNRS 6543, Centre Antoine Lacassagne, 33 Avenue 
      Valombrose, Nice Cedex, 06189, France.
FAU - Berra, E
AU  - Berra E
FAU - Pouyssegur, J
AU  - Pouyssegur J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Lymphokines)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 6.- (Ligases)
SB  - IM
MH  - Animals
MH  - *Cell Hypoxia
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Endothelial Growth Factors/biosynthesis
MH  - Hydrolysis
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - *Ligases
MH  - Lymphokines/biosynthesis
MH  - *Neovascularization, Pathologic
MH  - Nuclear Proteins/genetics/metabolism
MH  - Proteins/physiology
MH  - Signal Transduction
MH  - *Transcription Factors
MH  - *Tumor Suppressor Proteins
MH  - *Ubiquitin-Protein Ligases
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
MH  - Von Hippel-Lindau Tumor Suppressor Protein
RF  - 50
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0006-291X(99)91889-2 [pii]
AID - 10.1006/bbrc.1999.1889 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Dec 29;266(3):718-22. doi: 
      10.1006/bbrc.1999.1889.