PMID- 10605942
OWN - NLM
STAT- MEDLINE
DCOM- 20000112
LR  - 20190915
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 35
IP  - 3
DP  - 1999 Dec 1
TI  - Specific expression pattern of Fos in the accessory olfactory bulb of male mice 
      after exposure to soiled bedding of females.
PG  - 189-95
AB  - The heterogeneous structure of the accessory olfactory bulb (AOB) has been 
      demonstrated immunocytochemically. In this study, we analyzed the expression of 
      an immediate-early gene protein, c-Fos, as a marker of neuronal activity in 
      response to chemosensory cues was analyzed. The number of c-Fos-immunoreactive 
      (Fos-ir) cells was measured in the rostral and caudal zones of the AOB in male 
      ICR mice after exposure to the soiled bedding of female mice. The results 
      revealed no significant difference in the number of Fos-ir cells in the caudal 
      zone of the AOB between exposure to the soiled bedding of female ICR mice (ICR 
      group) and exposure to that of female Balb mice (Balb group). In the rostral 
      zone, however, the number of Fos-ir cells in the glomerular layer and granule 
      cell layer was larger in the ICR group than in the Balb group. The difference in 
      the expression of c-Fos in response to different pheromonal stimuli between the 
      rostral and caudal zones in the mouse AOB has been shown for the first time in 
      this study. These results strongly suggest that the heterogeneous structure of 
      the AOB has an important role in the perception and processing of pheromones.
FAU - Matsuoka, M
AU  - Matsuoka M
AD  - Japan Society for the Promotion of Science, Tokyo, Japan.
FAU - Yokosuka, M
AU  - Yokosuka M
FAU - Mori, Y
AU  - Mori Y
FAU - Ichikawa, M
AU  - Ichikawa M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurons/*metabolism
MH  - Olfactory Bulb/*metabolism
MH  - Pheromones/physiology
MH  - Proto-Oncogene Proteins c-fos/*analysis/*metabolism
MH  - Vomeronasal Organ/physiology
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0168-0102(99)00082-6 [pii]
AID - 10.1016/s0168-0102(99)00082-6 [doi]
PST - ppublish
SO  - Neurosci Res. 1999 Dec 1;35(3):189-95. doi: 10.1016/s0168-0102(99)00082-6.